Acylcarnitine: Useful biomarker for early diagnosis of hepatocellular carcinoma in non-steatohepatitis patients

doi:10.4251/wjgo.v11.i10.887

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Oct 15, 2019; 11(10): 887-897
Published online Oct 15, 2019. doi: 10.4251/wjgo.v11.i10.887

Table 2 Diagnostic accuracy of biomarkers for the early diagnosis of hepatocellular carcinoma

Variable	OR (95%CI)	P value
Univariate analysis
AFP > 10 ng/mL	1.67 (0.332-8.37)	0.535
DCP > 40 mAU/mL	8.00 (0.776-82.5)	0.0806
AFP-L3% > 5%	1.35 (0.999-1.84)	0.0221
VEGF > 60pg/mL	2.67 (0.630-1.3)	0.183
VEGFR-2 > 6500 pg/mL	2.83 (0.666-12.0)	0.159
Total carnitine (per 1 μmol/L increase)	0.979 (0.933-1.03)	0.380
Free carnitine (per 1 μmol/L increase)	0.991 (0.943-1.04)	0.710
Acylcarnitine (per 1 μmol/L increase)	0.0865 (0.0158-0.475)	0.0049
Multivariate analysis
Acylcarnitine (per 1 μmol/L increase)	0.0941 (0.00137-0.646)	0.0162

HCC: Hepatocellular carcinoma; AFP: α-Fetoprotein; DCP: Des-γ-carboxy prothrombin; AFP-L3%: Lens culinaris agglutinin-reactive α-fetoprotein; VEGF: Vascular endothelial growth factor; VEGFR-2: VEGF receptor-2; CI: Confidence interval; OR: Odds ratio.

Citation: Takaya H, Namisaki T, Kitade M, Shimozato N, Kaji K, Tsuji Y, Nakanishi K, Noguchi R, Fujinaga Y, Sawada Y, Saikawa S, Sato S, Kawaratani H, Moriya K, Akahane T, Yoshiji H. Acylcarnitine: Useful biomarker for early diagnosis of hepatocellular carcinoma in non-steatohepatitis patients. World J Gastrointest Oncol 2019; 11(10): 887-897
URL: https://www.wjgnet.com/1948-5204/full/v11/i10/887.htm
DOI: https://dx.doi.org/10.4251/wjgo.v11.i10.887