Albumin-to-alkaline phosphatase ratio: A novel prognostic index of overall survival in cholangiocarcinoma patients after surgery

Table 3 Univariate and multivariate analyses of factors in relation to recurrence free survival

Variable	Univariate		Multivariate
	HR (95%CI)	P value	HR (95%CI)	P value
Age, yr	1.31 (0.89-2.91)	0.381
≥ 60
≥ 60
Sex	1.0 (0.5–1.8)	0.300
Female
Male
Infectious diseases
HBV	1.91 (0.73-5.21)	0.212
HCV	2.45 (0.61–5.21)	0.374
Serum albumin level, g/L	0.89 (0.34-2.34)	0.171
≥ 35
< 35
ALP, ng/mL	1.96 (0.73–5.32)	0.212
≥ 20
< 20
AAPR	2.52 (1.38–4.75)	0.002	2.31 (1.40–3.29)	< 0.001
≥ 0.41
< 0.41
Tumor size, cm	3.62 (1.73–7.69)	0.010	1.92 (1.70–2.16)	< 0.001
≥ 5
< 5
Number of tumors	2.47 (1.21–5.23)	0.009	2.20 (1.41–4.87)	0.002
≥ 2
1
Stage (III + IV)	2.73 (1.81–3.55)	0.003	2.32 (1.26–3.53)	< 0.001

HR: Hazard ratio; AAPR: Albumin-to-alkaline phosphatase ratio; HBV: Hepatitis B virus; HCV: Hepatitis C virus; CCA: Cholangiocarcinoma; ALP: Alkaline phosphatase.