Colorectal carcinogenesis: Insights into the cell death and signal transduction pathways: A review

Figure 6 Delta/Notch Signalling. Notch signalling is initiated by the binding of Notch on one cell to the transmembrane ligands Delta or Jagged on a neighbouring cell. This binding interaction promotes cleavage of the Notch receptor and releases the Notch intracellular domain (NICD), which travels to the nucleus and controls the transcription of Notch responsive genes. In the nucleus, NICD binds to the transcriptional repressor CBF1, which recruits Mastermind-like (MAML) and other co-activators to initiate the transcription of downstream Notch-regulated genes.