Novel biomarkers for patient stratification in colorectal cancer: A review of definitions, emerging concepts, and data

Table 2 Candidate liquid biopsy/circulating miRNA biomarkers[145]

Expression level	Diagnostic biomarker	Prognostic biomarker (malignant potential, tumor recurrence)	Predictive biomarker (chemosensitivity)
High	miR-92a, miR-141, let-7a, miR-1229, miR-1246, miR-150, miR-21, miR-223, miR-23a, miR-378	miR-141, miR-320, miR-596, miR-203	miR-106a, miR-484, miR-130b
Low		miR-15a, miR-103, miR-148a, miR451

Adapted from Tsutomu Kawaguchi et al. Circulating MicroRNAs: A Next-Generation Clinical Biomarker for Digestive System Cancers. Int J Mol Sci 2016; 17: 1459.