Comparison of efficacy and safety between standard-dose and modified-dose FOLFIRINOX as a first-line treatment of pancreatic cancer

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Nov 15, 2018; 10(11): 421-430
Published online Nov 15, 2018. doi: 10.4251/wjgo.v10.i11.421

Table 4 Adverse events (≥ Grade 3) n (%)

Event	sFOLFIRINOX	mFOLFIRINOX	P value
Event	(n = 88)	(n = 42)	P value
Hematologic
Neutropenia	73 (83.0)	28 (66.7)	0.044¹
Febrile neutropenia	24 (27.3)	9 (21.4)	0.474
Anemia	19 (21.6)	11 (26.2)	0.561
Thrombocytopenia	8 (9.1)	2 (4.8)	0.499
Non-hematologic
Fatigue	33 (37.5)	14 (33.3)	0.644
Anorexia	43 (48.9)	12 (28.6)	0.029¹
Nausea/Vomiting	53 (60.2)	19 (45.2)	0.108
Diarrhea	12 (13.6)	0 (0.0)	0.009¹
Peripheral sensory neuropathy	12 (13.6)	2 (4.8)	0.224
Sepsis	5 (5.7)	0 (0.0)	0.174
Lung infection	3 (3.4)	4 (9.5)	0.212
Biliary tract infection	6 (6.8)	0 (0.0)	0.176

¹Values indicate statistical significance. mFOLFIRINOX: Modified FOLFIRINOX; sFOLFIRINOX: Standard FOLFIRINOX.

Citation: Kang H, Jo JH, Lee HS, Chung MJ, Bang S, Park SW, Song SY, Park JY. Comparison of efficacy and safety between standard-dose and modified-dose FOLFIRINOX as a first-line treatment of pancreatic cancer. World J Gastrointest Oncol 2018; 10(11): 421-430
URL: https://www.wjgnet.com/1948-5204/full/v10/i11/421.htm
DOI: https://dx.doi.org/10.4251/wjgo.v10.i11.421

Kang H, Jo JH, Lee HS, Chung MJ, Bang S, Park SW, Song SY, Park JY. Comparison of efficacy and safety between standard-dose and modified-dose FOLFIRINOX as a first-line treatment of pancreatic cancer. World J Gastrointest Oncol 2018; 10(11): 421-430 [PMID: 30487953 DOI: 10.4251/wjgo.v10.i11.421]

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