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©The Author(s) 2018.
World J Gastrointest Oncol. Nov 15, 2018; 10(11): 370-380
Published online Nov 15, 2018. doi: 10.4251/wjgo.v10.i11.370
Published online Nov 15, 2018. doi: 10.4251/wjgo.v10.i11.370
Table 2 Frequency of significantly mutated ampulla of Vater carcinoma genes in different histotypes and compared to colorectal and pancreatic adenocarcinoma (adapted from Yachida et al[14])
| Yachida et al[14] | Gingras et al[17] | Biankin et al[36] Pancreatic carcinoma, % | Colorectal Carcinoma (TCGA), %[35] | |||
| Intestinal type, % | Pancreato-biliary type, % | Mixed type, % | Pancreato-biliary type, % | Intestinal type, % | ||
| APC (50) | KRAS (68) | KRAS (50) | TP53 (72) | TP53 (65) | KRAS (99) | APC (81) |
| TP53 (39) | TP53 (67) | APC (50) | KRAS (65) | KRAS (46) | TP53 (33) | TP53 (60) |
| KRAS (39) | SMAD4 (20) | TP53 (41) | SMAD4 (18) | APC (41) | SMAD4 (16) | KRAS (43) |
| CTNNB1 (26) | CTNNB1 (15) | SMARCA4 (27) | CDKN2A (16) | PIK3CA (26) | MLL3 (7) | TTN (31) |
| ARID2 (18) | ERBB3 (14) | PIK3CA (23) | PIK3CA (13) | SMAD4 (20) | ATM (5) | PIK3CA (18) |
| ERBB2 (14) | GNAS (12) | SMAD 4 (23) | ARID1A (13) | TGFBR2 (17) | NALCN (5) | FBXW7 (14) |
| ACVR2A (13) | CDH10 (12) | SOX 9 (23) | APC (11) | ARID2 (17) | ARID1A (4) | SMAD4 (10) |
| SMAD4 (13) | ELF3 (11) | CDKN2A (23) | ATM (10) | ELF3 (7) | SF3B1 (4) | NRAS (9) |
| GNAS (13) | CDKN2A (9) | ARID1A (18) | TGFBR2 (10) | CTNNB1 (17) | TGFBR2 (4) | TCF7L2 (9) |
| SOX9 (13) | TGFBR2 (14) | FBXW7 (8) | NF1 (15) | ARID2 (3) | FAM123B (7) | |
- Citation: Pea A, Riva G, Bernasconi R, Sereni E, Lawlor RT, Scarpa A, Luchini C. Ampulla of Vater carcinoma: Molecular landscape and clinical implications. World J Gastrointest Oncol 2018; 10(11): 370-380
- URL: https://www.wjgnet.com/1948-5204/full/v10/i11/370.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v10.i11.370