Efficacy and safety of perioperative therapy for locally resectable gastric cancer: A network meta-analysis of randomized clinical trials

Figure 1  Flow diagram of article search and study selection.

Figure 2 Network meta-analysis of R0 resection rate. A: Network diagram of R0 resection rate; B: The published biased funnel plot of R0 resection rate; C: Comparisons between each treatment; D: Surface under the cumulative ranking value of R0 resection rate of each intervention. Bold and underlined indicate statistically significant pairwise comparisons. A: Neoadjuvant ECF; B: Neoadjuvant FLOT; C: Neoadjuvant DCS; D: Neoadjuvant CS; E: Neoadjuvant DCF; F: Neoadjuvant DOS; G: Neoadjuvant ECF plus Neoadjuvant Radiotherapy; H: Neoadjuvant FLO; I: Neoadjuvant SOX; J: Neoadjuvant XELOX; K: Neoadjuvant DOX; L: Neoadjuvant XELOX plus Neoadjuvant Radiotherapy; M: Neoadjuvant SOX plus Neoadjuvant Radiotherapy; N: Neoadjuvant CF; O: Neoadjuvant PC; P: Neoadjuvant FOLFOX; Q: Surgery alone.

Figure 3 Network meta-analysis of overall survival. A: Network diagram of overall survival; B: The published biased funnel plot of overall survival; C: Comparisons between each treatment. Bold and underlined indicate statistically significant pairwise comparisons. A: Neoadjuvant plus adjuvant FLOT; B: Neoadjuvant plus adjuvant ECF; C: Neoadjuvant plus adjuvant DCF; D: Adjuvant CapeOX; E: Neoadjuvant ECF plus adjuvant ECF and radiotherapy; F: Neoadjuvant DCS plus adjuvant S-1; G: Neoadjuvant CS plus adjuvant S-1; H: Neoadjuvant plus adjuvant XELOX; I: Neoadjuvant SOX and radiotherapy plus adjuvant SOX; J: Neoadjuvant plus adjuvant SOX; K: Neoadjuvant plus adjuvant CF; L: Neoadjuvant plus adjuvant FOLFOX; M: Adjuvant SOX; N: Surgery alone.

Figure 4 Network meta-analysis of non-surgical severe adverse events. A: Network diagram of higher nonsurgical severe adverse events (SAEs); B: The published biased funnel plot of non-surgical SAEs; C: Comparisons between each treatment. old and underlined indicate statistically significant pairwise comparisons; D: Surface under the cumulative ranking value of non-surgical SAEs of each intervention. A: Neoadjuvant plus adjuvant ECF, B: Neoadjuvant plus adjuvant FLOT, C: Neoadjuvant ECF plus adjuvant ECF and radiotherapy, D: Neoadjuvant plus adjuvant FLO, E: Neoadjuvant plus adjuvant SOX, F: Neoadjuvant DOX plus adjuvant SOX, G: Neoadjuvant plus adjuvant XELOX, H: Adjuvant XELOX, I: Neoadjuvant and radiotherapy plus adjuvant XELOX, J: Neoadjuvant SOX and radiotherapy plus adjuvant SOX, K: Adjuvant SOX, L: Neoadjuvant plus adjuvant FOLFOX.