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World J Gastrointest Oncol. Oct 15, 2022; 14(10): 1892-1902
Published online Oct 15, 2022. doi: 10.4251/wjgo.v14.i10.1892
Figure 1
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Figure 1 The position and structure of Go-Ichi-Ni-San 2. A: The chromosomal localization of Go-Ichi-Ni-San 2 (GINS2) (GeneCards, http://www.genecards.org); B: GINS2 expression is usually concentrated in the nucleus and cytosol (GeneCards, http://www.genecards.org); C: The structure of the GINS2 protein (AlphaFold Protein Structure Database, http://www.alphafold.ebi.ac.uk). The positions of the C- and N-termini and α-domains and β-domains in each subunit are indicated.
Figure 2
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Figure 2 The effect of Go-Ichi-Ni-San 2 on the malignant characteristics of tumour cells. GINS2: Go-Ichi-Ni-San 2; MAPK: Mitogen-activated protein kinase; ERK: Extracellular signal-regulated kinase; STAT: Signal transducers and activator; EMT: Epithelial-mesenchymal transition; ATM: Ataxia telangiectasia mutated.
Figure 3
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Figure 3 The participating pathways of Go-Ichi-Ni-San 2. GINS2: Go-Ichi-Ni-San 2; MAPK: Mitogen-activated protein kinase; ERK: Extracellular signal-regulated kinase; STAT: Signal transducers and activator; EMT: Epithelial-mesenchymal transition; MAPKKK: MAP kinase kinase kinase; MMPs: Matrix metalloproteinases; MEK: Mitogen-activated protein kinase; MKK3/6: MAP kinase kinase 3/6; MCM2: Minichromosome maintenance complex component 2; CHEK2: Checkpoint kinase 2; ATM: Ataxia telangiectasia mutated; CHK2: Cell kinase cyclecheckpoint2; PTP4A1: Protein tyrosine phosphatase 4A1; CITED2: Cbp/P300-interacting transcription factor 2; LOXL2: Lysyl oxidase like 2; GADD45A: Growth arrest and DNA damage inducible alpha; JAK: Janus kinase; mTOR: Mammalian target of rapamycin.