World J Gastrointest Endosc. 2013 February 16; 5(2): 74-78.
Published online 2013 February 16. doi: 10.4253/wjge.v5.i2.74.
Incidental finding of esophageal pneumatosis
Haritha Chelimilla, Jasbir S Makker and Anil Dev.
Haritha Chelimilla, Anil Dev, Division of Gastroenterology, Bronx Lebanon Hospital Center, Bronx, New York, NY 10457, United States
Jasbir S Makker, Department of Internal Medicine, Bronx Lebanon Hospital Center, Bronx, New York, NY 10457, United States
Author contributions: Chelimilla H, Makker JS and Dev A equally contributed to the manuscript writing and revision.
Correspondence to: Dr. Haritha Chelimilla, Gastroenterology Fellow, Division of Gastroenterology, Bronx Lebanon Hospital Center, Bronx, New York, NY 10457, United States. harichelimil@gmail.com
Telephone: +1-718-5185550 Fax: +1-718-5185111
Received October 5, 2012; Revised November 9, 2012; Accepted November 24, 2012;
Abstract
Pneumatosis of the gastrointestinal tract is a rare condition characterized by the presence of air filled cavities in the gastrointestinal tract wall. Its occurrence has been described throughout the gastrointestinal tract from the esophagus to the rectum, however it is most commonly reported in the small intestine. Despite multiple case reports in literature, its pathogenesis still remains unclear. Pneumatosis may be idiopathic or associated with a variety of disorders namely peptic ulcer disease, jejunoileal bypass, intestinal obstruction and non-gastrointestinal disorders like asthma, chronic obstructive pulmonary disease, systemic lupus erythematosus, infectious enteritis, etc. We here present a rare case of pneumatosis of the esophagus diagnosed incidentally at an esophagogastroduodenoscopy (EGD). A 78-year-old asymptomatic woman underwent EGD and colonoscopy at our hospital for evaluation of anemia. Few months prior to EGD, she had undergone excision of laryngocele at our hospital. EGD revealed extensive submucosal blebs distributed throughout the esophagus, otherwise unremarkable stomach and duodenum. Colonoscopy showed a tubular adenomatous polyp. Since our patient was asymptomatic she did not require any surgical intervention. Management of pneumatosis depends on the underlying cause.
Keywords: Pneumatosis, Esophagus, Esophagogastroduodenoscopy, Blebs, Laryngocele
INTRODUCTION
Pneumatosis of the gastrointestinal tract is well known in medical literature. It is characterized by the presence of air filled spaces in the submucosa and subserosa.
It can appear in different locations in the gastrointestinal tract from the esophagus to the rectum, but more commonly the small bowel is involved[1-4]. Pneumatosis of the gastrointestinal tract can be symptomatic or completely asymptomatic, where it is detected incidentally during endoscopy or autopsy. Clinical manifestations are variable and depend on the underlying clinical condition and the site of gastrointestinal tract involved. Commonly reported gastrointestinal symptoms include retrosternal chest pain, abdominal pain and gastrointestinal bleed. Initial evaluation of pneumatosis should be focussed on ruling out acute abdomen or sepsis and identification of the underlying pathology.
Pneumatosis involving the esophagus is a relatively rare condition. Ever since the first description of pneumatosis in medical literature about three centuries ago, only eight case reports of esophageal pneumatosis have been reported so far. We here report the ninth case of esophageal pneumatosis found incidentally on an esophagogastroduodenoscopy (EGD).
CASE REPORT
A 78-year-old African American woman was seen in our gastroenterology clinic for evaluation of anemia.
Five months before evaluation in the gastroenterology clinic, she was admitted to our hospital with symptoms of right-sided neck pain, dysphagia and sore throat of three days duration. She denied any shortness of breath, drooling of saliva, cough or chest pain. She reported no weight loss, fever or sick contacts.
Her medical history included diabetes mellitus, hypertension, sickle cell trait and chronic hepatitis C. She had no known allergies. She had smoked 1 pack per day for the past 50 years and had quit a year ago. She denied any alcohol or substance abuse.
She denied having any surgery in the past and her family history was unremarkable.
Initial vital signs and laboratory findings have been summarized in Tables 1 and 2 respectively. General physical examination showed a firm, nontender, non-mobile mass on the right side of the neck. Thyroid gland was normal on examination as was the remainder of the examination.
Table 1
Table 1
Vital signs on initial examination
Table 2
Table 2
Laboratory findings
Chest radiograph was normal. Computed tomography (CT) of neck soft tissue was obtained after intravenous contrast which revealed uniformly hypodense, loculated collection with well demarcated thin enhancing margin measuring 3.8 cm × 2.5 cm × 4.2 cm bordering the right oropharynx and extended from the palatine tonsils to the tip of the esophagus (Figure 1). Displacement of the upper air passage towards the left side was also noted. Patient was evaluated by ear nose and throat surgeon and was taken to operating room for excision of a possible infected laryngocele through a laryngotomy approach. Intraoperatively, approximately 5 cm × 7 cm cystic mass involving the larynx extending from the hyoid bone to the thyroid cartilage on the right side was noticed. The cyst extended through the thyrohyoid area into the larynx and communicated with the laryngeal vestibule. There was significant edema and fullness of the right aryepiglottic fold and supraglottic larynx, which obstructed view of the glottic airway. The patient required fiberoptic intubation for achieving general anesthesia.
Figure 1
Figure 1
Figure 1
Computed tomography neck soft tissue. A: Sagittal view of neck soft tissue (arrow); B: Transverse view of neck soft tissue (arrow).
After excision, a membranous saccular tissue measuring 4 cm × 2.8 cm × 0.3 cm was submitted for a pathological diagnosis, which later revealed respiratory epithelium-lined membranous fibrous tissue consistent with laryngocele (Figure 2). Pathological examination of the purulent fluid submitted with the laryngocele revealed acute inflammatory cell infiltrate comprising polymorphs, macrophages and cellular debris, and these features were suggestive of an abscess.
Figure 2
Figure 2
Figure 2
Hematoxylin and eosin stain. A: The respiratory epithelium lined membranous fibrous tissue (arrow) consistent with laryngocele (low power magnification); B: The laryngocele wall showing focal chronic inflammation and reactive lymphoid aggregates (arrows, high power magnification).
After the procedure, patient remained intubated with respiration supported on positive pressure mechanical ventilation for 11 d. Postoperative course was otherwise uneventful and patient was discharged home after a hospital stay of 2 wk.
Four months after discharge from the hospital, she was asymptomatic and seen in the clinic for evaluation of anemia. Upper gastrointestinal endoscopy was done which incidentally showed extensive submucosal blebs of the esophagus without any involvement of the stomach (Figure 3). There was gastric erythema with biopsy showing Helicobacter pylori gastritis. Colonoscopy was also performed at the same time, which revealed a tubular adenomatous polyp but otherwise unremarkable.
Figure 3
Figure 3
Figure 3
Endoscopic view of the esophagus. A: Endoscopic view of the esophagus showing the submucosal air blebs (arrows) throughout the esophagus; B: Magnified view of the pneumatosis of the esophagus on endoscopy. These air blebs (arrows) were seen throughout the esophagus.
DISCUSSION
Pneumatosis of the gastrointestinal tract was first reported in a cadaver in the year 1730 by Thorpe[5] and Du vernoi[6]. Later in the year 1876, pneumatosis intestinalis was reported in humans by Bang[7]. Since then numerous cases of pneumatosis of the gastrointestinal tract have been described. In 1979, Jamart reported a review of 919 cases of pneumatosis intestinalis and found that pneumatosis of small bowel was predominantly subserous and that of colon was submucosal in location[8]. Pneumatosis can involve any part of the gastrointestinal tract from the esophagus to the rectum, but has been reported more commonly in small bowel than large bowel. Cases of gastric pneumatosis have also been published but esophageal pneumatosis has been a rare occurrence.
On review of the available medical literature, we found eight cases (Table 3) of esophageal pneumatosis reported till date. Interestingly, most of these cases including our case as well were reported in females except for two cases. Vanasin et al[9], described the first case of esophageal pneumatosis in a 62 year old woman related to esophageal stricture. Katz et al[10] reported three cases of esophageal pneumatosis related to fiberesophagoscopy. Fifth case was described by McKelvie et al[11] in a 76-year-old man with infectious gastritis. Sixth case in a 74-year-old woman post duodeno-pancreatectomy was published in 1998 by Tixedor et al[12]. Mclaughlin et al[13] reported the seventh case of esophageal pneumatosis in a 77-year-old man who had underwent resection of cholangiocarcinoma. Yahng et al[14] reported the eighth case in a 62-year-old woman who developed esophageal pneumatosis post chemotherapy with neutropenia.
Table 3
Table 3
Esophageal pneumatosis case reports
Pneumatosis may be idiopathic or may occur secondary to underlying pathological process. These secondary forms of pneumatosis account for about 85% of total cases[15,16]. Pneumatosis intestinalis has been described in various medical conditions including necrotizing enterocolitis, pyloric stenosis, peptic ulcer disease, jejunoileal bypass, and intestinal obstruction. Besides being described in gastrointestinal disorders, it has also been reported in non-gastrointestinal disorders like asthma, chronic obstructive pulmonary disease, celiac disease, systemic lupus erythematosus, infectious enteritis, acquired immunodeficiency syndrome, primary immunodeficiency, leukemia, organ transplantation and bone marrow transplantation[3,17].
Despite several cases reported in literature, pathogenesis of pneumatosis remains unclear. Two important theories proposed among several other proposed are mechanical and bacterial theory. According to mechanical theory, air present in the gastrointestinal tract lumen dissects into the walls of the gastrointestinal tract through a mucosal tear. Bacterial theory proposes that the air entering the walls of bowel is produced by gas forming bacteria in the bowel.
In our patient, we hypothesize that resection of the laryngocele followed by positive pressure ventilation may have predisposed to the formation of the pneumatosis, and hence supporting mechanical theory. Other possible etiology in our patient could be the underlying chronic bronchitis secondary to long standing smoking.
Typically it is an asymptomatic condition as in our patient. However may have a broad spectrum of presentation from an incidental finding to retrosternal chest pain, abdominal pain or septic shock. Symptoms may vary depending upon site of gastrointestinal tract involved.
Work up includes radiographs of the chest and the abdomen. CT, magnetic resonance imaging and barium studies[3] can also be used, but CT has better sensitivity to detect intramural air[18,19].
Management largely depends on the underlying etiology. Various treatment modalities have been utilized in the past including oxygen therapy and antibiotic use. Normobaric oxygen therapy, after its first experimental use in 1935, was used successfully for treatment of pneumatosis by Forgacs et al[20]. Later in 1978, the use of hyperbaric oxygen was also shown to be beneficial by Masterson et al[21]. Antibiotic therapy with Metronidazole has also been reported to be efficacious in literature supporting the bacterial theory of genesis[22].
Algorithm for surgical management of pneumatosis has been suggested by Greenstein et al[23] in cases of obstruction, elevated white cell count, advanced age and portal venous gas. Endoscopic modalities of therapy with cyst puncture and sclerotherapy have also been described[24]. But with numerous case reports of success with conservative therapy, treatment of pneumatosis essentially remains non-surgical unless acute abdomen is suspected.
Footnotes
P- Reviewer Donati F S- Editor Gou SX L- Editor A E- Editor Zhang DN
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