Brief Article
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World J Gastrointest Endosc. Jun 16, 2013; 5(6): 281-287
Published online Jun 16, 2013. doi: 10.4253/wjge.v5.i6.281
Clinical outcomes and risk factors for perforation in gastric endoscopic submucosal dissection: A prospective pilot study
Jiro Watari, Toshihiko Tomita, Fumihiko Toyoshima, Jun Sakurai, Takashi Kondo, Haruki Asano, Takahisa Yamasaki, Takuya Okugawa, Hisatomo Ikehara, Tadayuki Oshima, Hirokazu Fukui, Hiroto Miwa
Jiro Watari, Toshihiko Tomita, Fumihiko Toyoshima, Jun Sakurai, Takashi Kondo, Haruki Asano, Takahisa Yamasaki, Takuya Okugawa, Hisatomo Ikehara, Tadayuki Oshima, Hirokazu Fukui, Hiroto Miwa, Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan
Author contributions: Watari J designed the study, analyzed the data, and wrote the manuscript; Watari J, Tomita T, Toyoshima F, Sakurai J, Kondo T, Asano H, Yamasaki T, Okugawa T, Ikehara H, Oshima T and Fukui H performed the endoscopic submucosal dissection procedure and collected physical and imaging findings; Miwa H provided appropriate advice for this work.
Correspondence to: Jiro Watari, MD, PhD, Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan. watarij@hyo-med.ac.jp
Telephone: +81-798-456662 Fax: +81-798-456661
Received: February 14, 2013
Revised: April 3, 2013
Accepted: April 18, 2013
Published online: June 16, 2013
Core Tip

Core tip: There has been little prospective study on the clinical outcomes of endoscopic perforation in endoscopic submucosal dissection for gastric neoplasia. In the current study, we investigated clinical outcomes of perforation during gastric endoscopic submucosal dissection, and analyzed various demographic and clinical parameters for risk factors. The results clearly demonstrated that prolonged procedure time (≥ 115 min), but not tumor location, was significantly associated with endoscopic perforation. The clinical outcomes of perforation are favorable and comparable to those with or without silent free air without endoscopic perforation as detected only by computed tomography.