Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Aug 16, 2021; 13(8): 275-295
Published online Aug 16, 2021. doi: 10.4253/wjge.v13.i8.275
Indications and outcomes of endoscopic resection for non-pedunculated colorectal lesions: A narrative review
Endrit Shahini, Diogo Libânio, Giacomo Lo Secco, Antonio Pisani, Alberto Arezzo
Endrit Shahini, Antonio Pisani, Department of Gastroenterology and Digestive Endoscopy Unit, National Institute of Research “Saverio De Bellis,” Castellana Grotte (Bari) 70013, Italy
Diogo Libânio, Department of Gastroenterology, Portuguese Oncology Institute, Porto 4200-072, Portugal
Giacomo Lo Secco, Alberto Arezzo, Department of Surgical Sciences, University of Torino, Turin 10126, Italy
Author contributions: Shahini E conducted study conceptualization, drafting the manuscript, data collecting, and curation; Shahini E, Libânio D, Lo Secco G, Pisani A, and Arezzo A conducted paper editing; Arezzo A supervised; all the authors have critically reviewed the data entries for important intellectual content, checked for completeness of information, reviewed, and approved the final draft.
Conflict-of-interest statement: The authors declare having no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Endrit Shahini, MD, MSc, Research Scientist, Department of Gastroenterology and Digestive Endoscopy Unit, National Institute of Research “Saverio De Bellis,” Via Turi 27, Castellana Grotte (Bari) 70013, Italy. endrit.shahini@irccsdebellis.it
Received: April 27, 2021
Peer-review started: April 27, 2021
First decision: June 13, 2021
Revised: June 14, 2021
Accepted: July 9, 2021
Article in press: July 9, 2021
Published online: August 16, 2021
Core Tip

Core Tip: The current unsolved dilemma concerns the necessity of a reliable submucosal invasive cancer assessment system, able to stratify the risk of the post-procedural need for surgery after endoscopic submucosal dissection of colorectal non-pedunculated lesions. It should be capable of selecting the at-risk subgroups of patients in whom endoscopic submucosal dissection could be the most suitable method. Accordingly, this narrative review aims to describe the best diagnostic strategies for predicting malignancy according to current endoscopic technology, to choose wisely among endoscopic mucosal resection, and endoscopic submucosal dissection procedures.