Hypothermia predicts hepatic failure after extensive hepatectomy in mice

Table 1 Univariate analysis of the factors before and after 75% partial hepatectomy

	24 h after PH			48 h after PH
	HT	NT	P value	HT	NT	P value
Surgery time (min)	12.5 ± 0.6	11.9 ± 0.4	NS	12.0 ± 0.4	12.0 ± 0.4	NS
Anesthesia time (min)	16.0 ± 0.6	15.2 ± 0.6	NS	15.3 ± 0.5	15.4 ± 0.3	NS
Estimated % of hepatectomy (%)	79.5 ± 1.8	77.1 ± 2.4	NS	76.1 ± 1.2	78.0 ± 0.1	NS
Remnant liver weight/body weight (%)	1.50 ± 0.03	1.73 ± 0.05	0.0002	1.74 ± 0.05	2.02 ± 0.05	< 0.0001
Last measured body temperature (°C)	24.4 ± 0.6	36.3 ± 0.2	< 0.0001	25.7 ± 0.7	36.1 ± 0.6	< 0.0001
AST (U/L)	1627 ± 722	342 ± 241	0.0124	1354 ± 514	51 ± 34	< 0.0001
ALT (U/L)	1389 ± 681	182 ± 34	0.0567	1465 ± 497	22 ± 7	0.0252
T-Bil (mg/dL)	12.9 ± 3.0	3.0 ± 0.5	0.0041	23.9 ± 3.1	3.1 ± 0.2	< 0.0001
Hb (g/dL)	9.5 ± 0.7	12.4 ± 0.5	0.0031	13.5 ± 0.8	12.5 ± 0.4	NS
Hematocrit (%)	28.0 ± 2.1	36.5 ± 1.4	0.0028	39.7 ± 2.3	36.7 ± 1.4	NS
Glucose (mg/dL)	133.9 ± 18.9	136.4 ± 5.1	NS	92.9 ± 11.7	128.9 ± 5.6	0.0117
PT- INR	0.9 ± 0.0	0.9 ± 0.0	NS	1.37 ± 0.24	1.84 ± 0.17	NS

The study mice were divided prospectively into two study groups according to their body temperature, i.e., hypothermic (HT) or normothermic (NT), at 24 and 48 h after surgery. NS: Not significant; AST: Aspartate aminotransferase; ALT: Alanine aminotransaminase; T-Bil: Total bilirubin; Hb: Hemoglobin; PT-INR: Prothrombin time-international normalized ratio; PH: Partial hepatectomy.

Table 2 Multivariate analysis of the factors before and after 75% partial hepatectomy

24 h after 75% PH (n = 152)	P value
Remnant liver weight/body weight	0.0829
Body temperature (°C)	0.0372
AST (U/L)	0.1263
ALT (U/L)	0.3826
T-Bil (mg/dL)	0.8753
Hb (g/dL)	0.6974
Hematocrit (%)	0.7365
48 h after 75% PH (n = 108)	P value
Remnant liver weight/body weight	0.0012
Body temperature (°C)	0.0161
AST (U/L)	0.9182
ALT (U/L)	0.8827
T-Bil (mg/dL)	0.7322
Glucose (mg/dL)	0.9913

PH: Partial hepatectomy; AST: Aspartate aminotransferase; ALT: Alanine aminotransaminase; T-Bil: Total bilirubin; Hb: Hemoglobin.