Efficacy and safety of telaprevir- and simeprevir-based triple therapies for older patients with chronic hepatitis C

Table 2 Patient characteristics by age (simeprevir)

Factors (median, range)	Patients aged < 66	Patients aged ≥ 66	P value
n	37	39	-
Gender, n (%) (male/female)	19/18 (48.6)	14/25 (64.1)	0.123
Age (yr)	59 (36-65)	71 (66-86)	< 0.001
Body weight (kg)	62.0 (39.8-94.0)	56.0 (37.5-76.6)	0.011
Body mass index (kg/m2)	22.8 (17.2-30.3)	22.7 (17.8-32.1)	0.287
Baseline HCV-RNA (log IU/mL)	6.7 (5.4-7.8)	6.6 (4.7-7.6)	0.631
White blood cells (/mm3)	4620 (2600-7800)	4300 (2400-8100)	0.010
Hemoglobin (g/dL)	13.8 (11.0-16.7)	13.1 (9.8-16.8)	< 0.001
Platelets (× 104/mm3)	16.4 (8.7-28.8)	16.3 (7.3-31.7)	0.291
Albumin (mg/dL)	4.2 (2.8-4.8)	4.0 (3.1-4.6)	0.002
AST (IU/L)	45 (21-159)	34 (19-128)	0.056
ALT (IU/L)	42 (16-316)	29 (12-112)	0.006
γ-GTP (IU/L)	29 (13-260)	27 (9-171)	0.388
Serum creatinine (mg/dL)	0.70 (0.44-1.01)	0.70 (0.42-1.36)	0.689
Estimated GFR (mL/min)	78.7 (50.0-112.6)	77.4 (41.3-109.0)	0.221
Prior treatment response, n (naïve/relapse/non-responder)	20/10/7	13/16/10	0.197
Liver histology (F0-2/3-4/ND)	12/6/19	19/5/15	0.483
IL28B SNP (rs8099917), n (TT/non-TT/ND)	17/19/1	18/17/4	1
HCV ISDR, n (0/1-3/4-/ND)	9/13/5/10	11/12/2/14	0.044
HCV Core 70, n (Wild/Mutant/ND)	17/13/7	15/8/16	1
HCV Core 91, n (Wild/Mutant/ND)	18/12/7	18/5/16	0.385

GFR: Glomerular filtration rate; IL28B SNP: Interleukin-28B single nucleotide polymorphism; ND: Not determined; ISDR: Interferon sensitivity-determining region; HCV core 70 or 91: At position 70 or 91 of the HCV core protein; HCV: Hepatitis C virus; AST: Aspartate transaminase; ALT: Alanine aminotransferase; γ-GTP: γ-glutamyl-transpeptidase.