Advanced non-alcoholic steatohepatitis cirrhosis: A high-risk population for pre-liver transplant portal vein thrombosis

Table 2 Baseline characteristics comparing high-risk non-alcoholic steatohepatitis to low-risk non-alcoholic steatohepatitis recipients

	High-risk NASH (n = 465)	Low-risk NASH (n = 2775)	P value
Recipient characteristics
Age at listing, mean years (95%CI)	64.0 (63.8-64.3)	56.7 (56.2-56.9)	< 0.001
Age at transplant, mean years (95%CI)	64.5 (64.2-64.7)	57.0 (56.8-57.4)	< 0.001
Male gender	247 (52.4)	1500 (53.0)	NS
African American race	7 (0.2)	58 (1.6)	NS
Hispanic race	43 (9.1)	305 (10.8)	NS
BMI at transplant, kg/m2, mean (95%CI)	35.1 (34.7-35.5)	31.8 (31.5-32.0)	< 0.001
Portal vein thrombosis	66 (14.2)	326 (11.8)	NS
Severity of liver disease
MELD score at listing, mean (95%CI)	19.5 (18.7-20.3)	20.1 (19.8-20.4)	NS
MELD score at transplantation, mean (95%CI)	22.8 (21.9-23.6)	23.7 (23.3-24.0)	NS
Laboratory values
Serum bilirubin, mg/dL, mean (95%CI)	6.2 (5.4-7.0)	7.7 (7.3-8.0)	0.002
INR, mean (95%CI)	1.81 (1.75-1.86)	1.94 (1.91-1.97)	0.002
Serum albumin, g/dL, mean (95%CI)	3.1 (3.0-3.2)	3.0 (2.9-3.1)	0.006
Creatinine, g/dL, mean (95%CI)	1.98 (1.85-2.11)	1.78 (1.73-1.83)	0.003
On dialysis at transplantation	73 (15.5)	415 (14.7)	NS
Portal hypertension manifestations
Moderate-severe ascites at transplant	178 (37.8)	1032 (36.5)	NS
Moderate-severe hepatic encephalopathy at transplant	51 (10.8)	324 (11.5)	NS

HR-NASH recipients were older, had higher BMI values and were more likely to have renal dysfunction. BMI: Body mass index; HR: High-risk; NASH: Non-alcoholic steatohepatitis; NS: Not significant; INR: International normalized ratio.