Advanced non-alcoholic steatohepatitis cirrhosis: A high-risk population for pre-liver transplant portal vein thrombosis

Table 1 Baseline characteristics comparing non-alcoholic steatohepatitis recipients to all other etiologies of liver disease n (%)

	NASH (n = 3240)	Other etiologies (n = 31832)	P value
Recipient characteristics
Age at listing, mean years (95%CI)	57.6 (57.3-57.9)	52.2 (52.1-52.3)	< 0.001
Age at transplant, mean years (95%CI)	58.1 (57.8-58.4)	52.7 (52.6-52.8)	< 0.001
Male gender	1747 (52.9)	22099 (67.3)	< 0.001
African American race	65 (2.0)	3.559 (10.9)	< 0.001
Hispanic race	348 (10.5)	4009 (12.2)	0.005
BMI at transplant, kg/m2, mean (95%CI)	32.3 (32.0-32.5)	27.8 (27.7-27.9)	< 0.001
Hypertension requiring medical treatment	160 (33.2)	2155 (19.2)	< 0.001
Diabetes	1698 (51.4)	6211 (18.9)	< 0.001
Portal vein thrombosis	394 (12.2)	2232 (7.1)	< 0.001
Etiology of liver disease
Alcohol alone		6236 (19.0)
Autoimmune disease		1.202 (3.7)
Cholestatic disease		3638 (11.1)
Hepatitis B		986 (3.0)
Hepatitis C		15298 (46.6)
Other		4472 (14.0)
Severity of liver disease
MELD score at listing, mean (95%CI)	20.0 (19.8-20.3)	19.6 (19.5-19.7)	0.014
MELD score at transplantation, mean (95%CI)	23.5 (23.2-23.8)	22.8 (22.7-22.9)	< 0.001
Laboratory values
Serum bilirubin, mg/dL, mean (95%CI)	7.4 (7.1-7.8)	9.1 (9.0-9.2)	< 0.001
INR, mean (95%CI)	1.92 (1.90-1.95)	1.93 (1.92-1.94)	NS
Serum albumin, g/dL, mean (95%CI)	3.0 (3.0-3.1)	3.0 (2.9-3.0)	0.002
Creatinine, g/dL, mean (95%CI)	1.81 (1.76-1.86)	1.65 (1.63-1.67)	< 0.001
On dialysis at transplantation	488 (10.6)	4135 (12.2)	< 0.001
Portal hypertension manifestations
Moderate-severe ascites at transplant	1210 (36.7)	10782 (32.9)	< 0.001
Moderate-severe hepatic encephalopathy at transplant	375 (11.7)	3708 (11.3)	NS

In general, NASH recipients were older, more likely to be female, less likely to be African American or Hispanic, had higher BMI values and were more likely to have diabetes, hypertension and renal dysfunction. BMI: Body mass index; NASH: Non-alcoholic steatohepatitis; NS: Not significant; INR: International normalized ratio; MELD: Model for end-stage liver disease.