Cockcroft-Gault revisited: New de-liver-ance on recommendations for use in cirrhosis

Table 2 Estimating creatinine clearance in morbidly obese patients by Demirovic et al[15] showed that using fat free weight and lean body weight provided the closest estimate to the control 24-h urine creatinine clearance

Method1	Mean estimated CrCl ± SD	Mean bias (mL/min)	± 30% of measured CrCl	± 50% of measured CrCl
Measured CrCl	109.5 ± 44.4
ActBW	217 ± 113	-107	13%	30%
IBW	85 ± 29	+24	48%	89%
AdjBW0.3	129 ± 55	-20	54%	76%
AdjBW0.4	142 ± 63	-33	52%	67%
FFW	103 ± 48	+7	61%	83%
LBW	102 ± 43	+8	56%	87%
MDRD4	96.3 ± 29.4	+13.3	51.90%	87%
Salazar-Corcoran	155.2 ± 65.1	-45.7	46.20%	55.60%

¹All weight variables used in CG equation only. MDRD4[18]: 186 × SCr^-1.154× age^-0.203× (0.742 if female) × (1.210 if black); Salazar-Corcoran[19]: Male: (137 - age) × [(0.285 × Wt) + (12.1 × height meters)²], 51 × SCr; Female: (146 - age) × [(0.287 × Wt) + (9.74 × height meters)²], 60 × SCr; ActBW: Actual body weight; AdjBW_0.3: 30% adjusted body weight; AdjBW_0.4: 40% adjusted body weight; CG: Cockcroft-Gault; CrCl: Creatinine clearance; FFW: Fat free weight; IBW: Ideal body weight; LBW: Lean body weight; MDRD: Modification of diet in renal disease study equation; SD: Standard deviation; Wt: Weight.