T-cell allorecognition of donor glutathione S-transferase T1 in plasma cell-rich rejection

Table 5 Identification of several regions of the glutathione S-transferase T1 protein, whose peptides would be suitable to be presented by human leukocyte antigen class I and II alleles of the patients based on in silico predictions

Recipient’s HLA	Peptide sequence	Aa position	Length	Percentile rank
Class I
A*01:01	FTLTESVAILLY1	62-73	12	0.1
A*02:01	YIFAKKNDIPFEL	18-30	13	0.1
	CLRALWHKVMFPV	110-122	13	0.1
	IKQKLMPWVLAMI	227-239	13	0.1
A*03:01	SVAILLYLTRKYK1	67-79	13	0.2
A*11:01	ESVAILLYLTRK1	66-77	12	0.1
A*29:02	FLTESVAILLY1	62-73	12	0.2
B*07:02	SPQTLAATLAEL	129-140	12	0.1
	RPKLATWRQRVEAA	188-201	14	0.2
B*08:01	FAQVNPLKKVPAL	45-57	13	0.2
	LAWQHTTLRRSCL	99-111	13	0.2
	DPTIKQKLMPWVL	224-236	13	0.2
B*35:01	YPQDLQARARVDEY	85-98	14	0.1
B*44:02	TESVAILLY1	65-73	9	0.15
	AELDVTLQL	138-146	9	0.15
Class II
DRB1*01:03	GDFTLTESVAILLYL1	60-74	15	0.6
DRB1*07:01	ALKDGDFTLTESVAI1	56-70	15	0.4
DRB1*11:01	AILLYLTRKYKVPDY1	69-83	15	0.5
DRB1*12:01	SVAILLYLTRKYKVP1	67-81	15	0.72
DRB1*13:01	LTESVAILLYLTRKY1	64-78	15	0.17
DRB1*14:01	SVAILLYLTRKYKVP1	67-81	15	0.48
DRB1*15:01	ESVAILLYLTRKYKV1	66-80	15	0.41

¹Highly antigenic areas of the GSTT1 protein whose peptides are shared by HLA class I and II alleles. GSTT1: Glutathione S-transferase T1; HLA: Human leukocyte antigen.