Low serum albumin predicts early mortality in patients with severe hypoxic hepatitis

Table 1 Clinical characteristics of patients with severe hypoxic hepatitis n (%)

	n = 75
Demographics
Age	61.9 ± 16.6
Male gender	43 (57.3)
Race (Chinese/Malay/Indian)	51/20/4 (68/26.7/5.3)
Pre-existing co-morbidities
Pre-existing ischemic heart disease	41 (54.7)
Pre-existing cardiac failure	27 (36.0)
Pre-existing renal failure	27 (36.0)
Pre-existing chronic viral hepatitis	5 (6.7)
Precipitating conditions
Documented hypotension	55 (73.3)
Documented bradycardia	11 (14.7)
Documented metabolic acidosis	43 (57.3)
Baseline laboratory parameters1
Albumin (g/L)	25.3 ± 6.9
Bilirubin (μmol/L)	76.1 ± 82.6
GGT (U/L)	126 ± 90
Creatinine (mmol/L)	321 ± 211
Prothrombin time (seconds)	27.8 ± 12.2
ALT (U/L)	2295 ± 1656
AST (U/L)	4896 ± 2986
ALT/AST ratio_D12	0.70 ± 1.36
Peak ALT (U/L)	2834 ± 1938
Peak AST (U/L)	5894 ± 3148
Clinical outcome
Admitted to ICU	50 (66.7)
Died within same admission	53 (70.7)

¹Measured at onset of severe hypoxic hepatitis;

²Ratio of the ALT to AST at the first documentation of either ALT or AST > 3000U/L. AST: Aspartate transaminase; ALT: Alanine transaminase; GGT: Gamma glutamyl transferase; ICU: Intensive care unit.