Inducible protein-10 as a predictive marker of antiviral hepatitis C treatment: A systematic review

Table 7 Overview of rapid virological response in the 3 studies providing information on baseline inducible protein-10’s, and hepatitis C virus RNA levels at week 4

Ref.	Patients (n)	IP-10 measurement method	Genotype (n)	Baseline IP-10 concentration, grouped by rapid virological response (pg/mL)			Overall RVR (n)
				RVR	Non-RVR	P-value	RVR	Non-RVR
Lagging et al[34]	170	ELISA (Quantikine, R and D systems, Minneapolis, MN, United States)	1 (170)	222	401	P < 0.01 (median)	33	137
1Fattovich et al[21]	226	ELISA (Quantikine, R and D systems, Minneapolis, MN, United States)	1 (92)	2.4 (± 0.28)	2.6 (± 0.25)	P < 0.01 (log mean ± SD)	172	108
			2 (87)	2.38 (± 0.31)	2.3 (± 0.30)	P > 0.05 (log mean ± SD)
			3 (47)	2.45 (± 0.23)	2.48 (± 0.39)	P > 0.05 (log mean ± SD)
Al-Ashgar et al[19]	64	ELISA (Quantikine, R and D systems, Minneapolis, MN, United States)	4 (64)	483.9 (± 261.6)	609.9 (±424.3)	P > 0.05 (mean ± SD)	12	52

¹Entire patient population was 280, genotype 4 infected were removed from the analyses, and IP-10 results was available for 226 patients. IP-10: Inducible protein-10; RVR: Rapid virological response.