Management of centrally located hepatocellular carcinoma: Update 2016

Table 1 Surgical treatment of centrally located hepatocellular carcinoma

Years	Patients’ number	Surgical approaches	Operative variables and outcomes
1993	19	Extended major hepatectomy or irregular hepatectomy (large tumor)	Mean operative blood loss: 1186.6 mL
			Mean operative time: 7.5 h
			One year overall survival rate: 84.2%
			One year recurrence-free survival rate: 73.7%[65]
1999	15	Mesohepatectomy	Mean operative blood loss: 2450 mL
			Hospital stay: 14.9 d
			Six year overall survival rate: 30%
			Six year recurrence-free survival rate: 21%[2]
2000	18	Mesohepatectomy	Mean operative time: 238 min
			Mean operative blood loss: 914 mL
			Hospital stay: 9 d[66]
2003	52	Central hepatectomy	Blood transfusion was needed: 1030 ± 1320 mL
			Bile leak occurred in 4 patients
			The median overall survival: 51 mo[35]
2007	246	Mesohepatectomy (larger tumor)	Mean operative blood loss (without pre-TACE): 420 mL
			Overall hospital mortality (without pre-TACE): 0.6%
			Five year overall survival rate (without pre-TACE): 31.7%[27]
2008	27	Central bisectionectomy	Median operative time: 330 min
			Twelve patients had postoperative complications and two died
			Bile duct injury was the most common complication[36]
2012	104	Hemi-/extended hepatectomy and central hepatectomy	Mean blood loss of hemi-/extended hepatectomy and central hepatectomy: 750 mL and 500 mL
			Five year overall survival rate for hemi-/extended hepatectomy and central hepatectomy: 66.2% and 53.1%
			Five year recurrence-free survival rate for hemi-/extended hepatectomy and central hepatectomy: 38.9% and 15%[67]
2013	292	Mesohepatectomy	Mean operative time: 259 min
			Mean operative blood loss: 634 mL
			Hospital stay: 10 d[68]
2014	350	Mesohepatectomy	Mean blood loss for large tumor: 950.7 mL
			Ascites was the most common complication
			Five year overall survival rate for larger tumor: 30%[69]
2014	24	Mesohepatectomy	Mean operative time: 238 min
			Mean operative blood loss: 480 mL
			Three year overall survival rate: 46%[70]
2014	198	Extended hepatectomy and mesohepatectomy	The  biliary leakage incidence after mesohepatectomy: 10.2%
			Five year overall survival rate for mesohepatectomy: 28.9%
			Five year recurrence free survival rate for mesohepatectomy: 16.9%[71]
2014	119	Hepatectomy with narrow margin	Bile leak occurred in 4 patients
			Five year overall survival rate: 48.3%
			Five year recurrence-free survival rate: 27.8%[3]
2015	69	Hemi-/extended hepatectomy and central hepatectomy	Mean blood loss of hemi-/extended hepatectomy and central hepatectomy: 522.2 mL and 447.8 mL
			Hospital stay for hemi-/extended hepatectomy and central hepatectomy: 21.3 and 14.9 d
			Three year overall survival rate for hemi-/extended hepatectomy and central hepatectomy: 64% and 61%[72]
2016	353	Mesohepatectomy	Five year overall survival rate: 40.2%
			Five year recurrence-free survival rate: 30.7%[4]

TACE: Transcatheter arterial chemoembolization.