Drug-induced liver injury: Do we know everything?

Table 3 R values[105]

Calculation of R value

ALT/AST value divided by its ULN = fold elevation/fold elevation above ULN for alkaline phosphatise

Definitions

Hepatocellular injury = R > 5

Cholestatic injury = R < 2

Mixed injury = R > 2 < 5

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ULN: Upper limit of normal.