Lycopene modulates cellular proliferation, glycolysis and hepatic ultrastructure during hepatocellular carcinoma

Table 3 Comparative analysis of the N-Nitrosodiethylamine and lycopene extracted from tomatoes + N-Nitrosodiethylamine group by transmission electron microscopy

Groups/parameters	NDEA	LycT + NDEA
Hepatocytes	Rounded, smaller in size	Polygonal but rounded edges
Nucleus	Large and irregular shape	Oval shaped
Nuclear membrane	Not uniform and pseudoinclusions	Not uniform
Nucleoli	Large, irregular, multiple	One-two
Nuclear/cytoplasmic ratio	High	Low
Karyotin (reticular material)	Deposition along nuclear membrane	Fewer karyotin deposits
Cytoplasm	Loss of organization, dense	Organized
Mitochondria	Pleomorphic with increased density	Pleomorphic but number less than that in the NDEA group
Lysosomes	Few in number	High in number
Fat and glycogen globules	Variable	High
Macrophages	Very few	Many
Apoptotic bodies	No	Clearly visible in the section

LycT: Lycopene extracted from tomatoes; NDEA: N-Nitrosodiethylamine.