Liver resection for intermediate hepatocellular carcinoma

Table 3 Prognostic risk factors of overall survival and disease-free survival

Ref.	Prognostic factors of overall survival		Prognostic factors of disease-free survival
	By univariate analysis	By multivariate analysis	By univariate analysis	By multivariate analysis
Ng et al[38]	Hepatitis B surface antigen carrier, serum AFP, symptomatic disease, presence of cirrhosis, number of tumor nodule, microvascular tumor invasion, tumor invasion of adjacent organs, histological margin involvement by tumor	Symptomatic disease, presence of cirrhosis, multi-nodular tumor, microvascular tumor invasion, positive histological margin	Serum AFP level, symptomatic disease, presence of cirrhosis, multi-nodular tumor, microvascular tumor invasion, tumor invasion of adjacent organ, positive histological margins, the presence of microsatellite nodules	Symptomatic disease, presence of cirrhosis, multi-nodular tumor, positive histological margins
Torzilli et al[44]	Tumor size, tumor grade	Tumor size, tumor grade	NR	NR
Chang et al[43]	NR	Serum albumin level, ICG-15R, serum creatinine, multi-nodularity, Edmondson stage, macro-vascular invasion	NR	NR
Ma et al[49]	Histopathological grade, tumor capsule, tumor number, cirrhosis, BCLC classification	Tumor capsule, BCLC classification	NR	Tumor capsule, BCLC classification
Torzilli et al[41]	Tumor number, tumor size, macro-vascular invasion, presence of cirrhosis, esophageal varices, major resection, BCLC classification, preoperative bilirubin values	NR	NR	NR
Cucchetti et al[35]	NR	Tumor number, presence of esophageal varices, Child-Pugh score	NR	NR
Cho et al[39]	Child-Pugh class B, AFP level > 400 ng/mL, histologically poor differentiation	Child-Pugh class B	Positivity of hepatitis B surface antigen, Child-Pugh class B, AFP level > 400 ng/mL, microvascular invasion, histologically poor differentiation	Child-Pugh class B, microvascular invasion
Yamashita et al[42]	NR	T4 status of HCC stage by liver cancer study group of Japan, thrombus in portal vein	NR	T4 status of HCC stage by liver cancer study group of Japan, intra-operative transfusion
Lin et al[26]	NR	Low albumin level, treatment modality (liver resection vs TACE)	NR	NR
Hsu et al[27]	NR	Serum AFP level, Child-Pugh class B, performance status ≥ 2, TACE, tumor size, vascular invasion	NR	NR
Zhong et al[28]	NR	Serum AFP ≥ 400 ng/mL, diabetes mellitus, macro-vascular invasion, portal hypertension, TACE treatment	NR	NR
Yin et al[31]	Treatment modality, serum AFP level, total tumor size, tumor number, gender	Tumor number, treatment modality, gender	NR	NR

TACE: Transhepatic arterial chemotherapy and embolization; NR: Not reported; HCC: Hepatocellular carcinoma; BCLC: Barcelona Clinic Liver Cancer; AFP: Alpha fetoprotein.