Incidence, risk factors and outcomes of de novo malignancies post liver transplantation

Table 3 A summary of ranges of reported overall incidence rates and standardized incidence ratios of a number of cancer types following liver transplantation[2-5,7-12,14-16,28,36,47,66,110,118-120]

	Incidence (%)	SIR
Skin cancers
Represent 24%-54% of all cancers, average 37%
Overall (non-melanoma)	0.9-11.6	2.1-70, average 24
Squamous cell cancer	0.6-15.3	Not reported
Basal cell cancer	0.6-10.6	Not reported
KS	0.2-1.4	128-144
Melanoma	0.2-3.9	4.4
Post-transplant lymphoproliferative disorders
Represent 4%-57% of all cancers, average 25%
Overall	0.5-2.9	3.9-21, average 12
Hodgkin’s lymphoma	0.001-0.4	8.2-8.9
Non-Hodgkin's lymphoma	0.8-3.7	3.5-37.3
Solid organ cancers
Represent 24%-75% of all cancers, average 48%
Overall	1.4-7.5	1.4-3.1, average 2.3
Lip	1.8	14-24.8
Oropharyngeal	1.7-1.9	7-10
Lung	0.6-2.4	1.4-2.0
Stomach	0.2-0.7	0.5-3.7
Colorectal	0.5-1.1	1.4-4.9
Breast (in females)	0.2-0.6	0.6-1.61
Cervix (in females)	0.7-1.4	1.3-5.7
Prostate (in males)	0.2-1.8	0.6-1.61

¹The SIR was not found to be significantly higher for transplant recipients compared with the reference population. Of note, studies often reported either incidence rate or SIR, but rarely both values. SIR: Standardized incidence ratio; KS: Kaposi’s sarcoma.