Metabolomics studies identify novel diagnostic and prognostic indicators in patients with alcoholic hepatitis

Table 4 Utility of biomarkers in differentiating cirrhosis with alcoholic hepatitis from cirrhosis with acute decompensation from etiologies other than alcohol: Receiver operating characteristics analysis

Biomarker	AUC (95%CI)
Citrulline and betaine	0.835 (0.747, 0.978)
Betaine and phenylalanine	0.810 (0.684, 0.937)
Citrulline and phenylalanine	0.758 (0.609, 0.907)
Citrulline	0.758 (0.610, 0.907)
Betaine	0.732 (0.588, 0.877)
Phenylalanine	0.715 (0.567, 0.863)
Crotonobetaine	0.663 (0.498, 0.827)
Tyrosine	0.650 (0.484, 0.817)
Butyrobetaine	0.649 (0.489, 0.808)
Creatinine	0.645 (0.486, 0.805)
Octenoyl-carnitine	0.631 (0.488, 0.774)
Propionyl-carnitine	0.620 (0.453, 0.787)
Homocitrulline	0.618 (0.457, 0.779)
Trimethyl-lysine	0.616 (0.447, 0.784)
Butyryl-carnitine	0.615 (0.451, 0.778)
Pentanoyl-carnitine	0.613 (0.455, 0.771)
Choline	0.597 (0.432, 0.762)
Valine	0.588 (0.424, 0.752)
Lysine	0.559 (0.393, 0.725)
Methyl-lysine	0.552 (0.383, 0.721)
Iso-leucine	0.548 (0.379, 0.716)
Acetyl-carnitine	0.543 (0.375, 0.710)
Hexanoyl-carnitine	0.529 (0.362, 0.696)
TMAO	0.521 (0.347, 0.695)
Argine	0.507 (0.339, 0.675)
ADMA	0.481 (0.314, 0.647)
Leucine	0.477 (0.309, 0.644)
Carnitine	0.470 (0.301, 0.638)
MMA	0.453 (0.286, 0.620)
SDMA	0.447 (0.277, 0.617)
Dimethyl-lysine	0.417 (0.243, 0.592)
Ornithine	0.351 (0.186, 0.517)

AUC: Area under receiver operating characteristics curve; ADMA: Asymmetric dimethylarginine; SDMA: Symmetric dimethylarginine; MMA: Monomethylarginine; TMAO: Trimethylamine N-oxide.