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Copyright ©The Author(s) 2016.
World J Hepatol. Jan 8, 2016; 8(1): 1-8
Published online Jan 8, 2016. doi: 10.4254/wjh.v8.i1.1
Table 2 Summary of metabolomic studies of hepatitis B virus-related liver cirrhosis
Ref.YearSpeciesTissuePlatformUp-regulatedDown-regulated
Liu et al[42]2013HumanSerumNMRL-phenylalanine, C16 sphinganine, alpha-CEHC, LysoPC (18:1), linoelaidic acid, PC (18:4/20:1), bilirubinL-carnitine, decanoyl-L-carnitine, phytosphingosine, 3α, 6α, 7α, 12α-tetrahydroxy-5β-cholan-24-oic acid PC (14:1/14:1), LysoPC (16:0)
LC 42LC-MS
N 18
LC/N
Wang et al[39]2012HumanUrineGC-MSProlile, citrate, aconitate, 3,4-dihydroxyphenylacetate, taurohyocholate, glycocholate, glycoursodeoxycholateThreonine, hippurate, 2-aminobutyrate, cis-aconitate, pyroglutamate, alpha-hydroxyisobutyrate, 3-hydroxyisovalerate, alpha-hydroxyhippurate, estrone
LC 63UPLC-TOFMS
N 31
LC/N
Zhou et al[23]2012HumanSerumLC-MSGCA, GCDCA, CNTryptophan, LysoPC (20:5), LysoPC (0:0/14:0), LysoPC (22:6), LysoPC (14:0/0:0), LysoPE (20:4), C10-CN, C10:1-CN, C8-CN, C6-CN
CIR 30
N 30
CIR/N
Yin et al[41]2009HumanSerumRRLCTaurocholic acid fragment, GCA, bilirubin, TCDCA fragment, GCDCA, oleic acid fragment, taurocholic acid fragment, carnitine fragment, L-acetylcarnitineHypoxanthine, lysoPC C18:2, LPC C18:3, LPC C16:1, LPC C18:0, Hypoxanthine fragment, inosine, taurine, 6-methylnicotinic acid
LC25 N25
LC/N
Xue et al[40]2009HBV infected humanSerumGC-MSAcetic acid, hexanoic acid, 1-naphthalenamine, butanoic acidSorbitol, D-Lactic acid, phosphoric acid, D-glucitol, glucose
LC20 non-LC 20
LC/non-LC