Composite prognostic models across the non-alcoholic fatty liver disease spectrum: Clinical application in developing countries

Table 2 Composite diagnostic models for non-alcoholic steatohepatitis

Biomarker panel	Components	Formula	AUC	Ref.
HAIR score	Hypertension	Weighted sum (0-4)	0.9	Dixon et al[52]
	Elevated ALT (> 40 IU/L)
	Insulin Resistance (index > 5)
Gholam's model	DM II	Algorithm	0.9	Gholam et al[53]
	AST level
NASH clinical scoring system for morbid obesity	Hypertension	Weighted sum (0-7)	Not reported	Campos et al[54]
	DM II
	Elevated AST (> 27 IU/L)
	Elevated ALT (> 27 IU/L)
	OSA
	non-black race
Ulitsky's score	DM II	Weighted sum (0-5)	Not reported	Ulitsky et al[55]
	Elevated ALT (> 40 IU/L)
	Elevated triglycerides (> 150 mg/dL)
	OSA
NASH predictive index	Female sex	Algorithm	0.78	Zein et al[56]
	Body mass index
	HOMA-IR
	AST levels
	ALT levels

AUC: Area under curve; ALT: Alanine aminotransferase; DM II: Diabetes mellitus type II; AST: Aspartate aminotransferase; OSA: Obstructive sleep apnoea; HOMA-IR: Homeostatic Measurement Assessment of Insulin Resistance; NASH: Non-alcoholic steatohepatitis.