Hepatitis C virus syndrome: A constellation of organ- and non-organ specific autoimmune disorders, B-cell non-Hodgkin’s lymphoma, and cancer

Figure 4 The main serological, clinical, and pathological hallmarks of mixed cryoglobulinemia syndrome, or cryoglobulinemic vasculitis: A: On the right serum cryoprecipitate (evaluated after 7 d storage at 4 °C) composed by polyclonal IgG (autoantigen) and monoclonal IgMk (autoantibody) immune-complexes, compared to normal serum sample; B: Recent onset, palpable purpuric lesions of the lower limbs; C: Sock-like ochraceous hyperpigmentation of the legs and feet, consequence of repeated episodes of purpura; D: Severe, necrotizing vasculitic skin lesion of the leg; E: Typical histological pattern of cutaneous leukocytoclastic vasculitis involving the small vessels and characterized by diffuse fibrinoid necrosis and disintegrated neutrophil permeation of the vessel walls; F: Wide non-healing skin ulcer, often resistant to treatment.