Hepatitis C in hemodialysis patients

Table 1 Histological features in hepatitis C virus infected hemodialysis patients

Ref.	Study design/country	No. of patients	Control group	Histological features	Milderhistology in HD as conclusion
Barril[50]	Multicenter observational/ Spain	n = 218 HD pts	None	70% chronic hepatitis 3% steatosis 15% cirrhosis	(+/-)
		Rebiopsy after 7 yr (n = 181)		74% stable disease 11% progression
Trevizoli et al[48]	Case-control study/Brasil	n = 36 aHCV(+) HD pts	n = 37 aHCV(+) with normal renal function	HD pts vs control group: Hepatic fibrosis 47.2% vs 73% (P < 0.025) Inflammatory activity 27.7% vs 59.5 % (P = 0.003)	(++)
Mysorekar et al[51]	Observational/ India	n = 45 aHCV(+) HD pts	None	67% (n = 30/45) mild inflammatory activity+mild fibrosis (stage 0, 1, 2)	(+/-)
Sterling et al[31]	Prospective case-contrrol study/United States	n = 50 aHCV(+) HD pts (transplant candidates)	Two A.Normal renal function, normal ALT (n = 43) B.Normal renal function, ↑ALT (n = 43)	Advanced liver disease (bridging fibrosis/cirrhosis) in 22% of HD pts vs 12% in group A (NS) and 48% in group B (P < 0.001) Mild hepatic inflammation in 62% of HD pts (score1-3) vs 36% in control groups A and B (P < 0.0001)	(++)
Cotler et al[30]	Case-control study/United States	n = 46 aHCV(+) HD pts	n = 46 aHCV (+) with normal renal function	HD pts vs control group: Less inflammatory activity (P < 0.001) Less bridging fibrosis/cirrhosis (13% vs 30%, P = 0.043)	(++)
Aslinia et al[49]	Cross sectional/United States	n = 156 aHCV(+) HD pts	n = 138 aHCV(+) with normal renal function	HD pts vs control group: Less necroinflammation (P < 0.05) Less fibrosis (P < 0.0001)	(++)
Becker et al[19]	Brasil	n = 216 aHCV(+) HD pts	None	77% absence of septal fibrosis (F0, F1) 12% F2 7% F3	(+)
Sakellariou et al[18]	Comparative analysis/Greece	n = 61 aHCV(+) HD pts	n = 326 non-HD, aHCV(+) pts	4% cirrhosis HD pts vs control group: Milder stage (P = 0.033) Lower grade (periportal activity, portal inflammation, lobular activity) (P < 0.001) Lower frequency of: Lymphoid aggregates (10.2% vs 50%, P < 0.001) Bile duct lesions (1.7% vs 22.1%, P < 0.001) Less extent of steatosis in HD pts (P = 0.022)	(++)

HD: Hemodialysis; HCV: Hepatitis C virus; ALT: Aminotransferase.