Spontaneous bacterial peritonitis: The clinical challenge of a leaky gut and a cirrhotic liver

Table 2 Randomised controlled trials concerning antibiotic treatment of spontaneous bacterial peritonitis

Ref.	No. of patients	Study arms	Resolution of infection	P	Comment
Felisart et al[117]	73	Ampicillin + tobramycin vs cefotaxime	56% vs 85%	< 0.02	Also patients without SBP included
Rimola et al[118]	143	Cefotaxime 8 g/24 h vs 4 g/24 h	77% vs 79%	NS
Navasa et al[119]	123	Ofloxacin po vs cefotaxime iv	84% vs 85%	NS	Only patients with uncomplicated SBP included
Ricart et al[120]	48	Amoxicillin-clavulanic acid vs cefotaxime	88% vs 83%	NS
Terg et al[121]	80	Ciprofloxacin only iv vs 2 d iv then po	76 vs 78%	NS
Piano et al[86] (NCT01455246) (preliminary results presented at the AASLD 2014, Abstract 574)	32	Daptomycin + meropenem vs ceftazidime	87% vs 25%	< 0.001	Only patients with nosocomial SBP included

NS: Not significant; SBP: Spontaneous bacterial peritonitis.