Genotypes and viral variants in chronic hepatitis B: A review of epidemiology and clinical relevance

Table 3 Clinical associations with hepatitis B virus genotypes

	A	B	C	D	E	F
Progression to chronicity	+++	++	+++	++
Histological inflammation	++	++	+++	+++		+/-
Histological fibrosis	+	+	++	++		+/-
Association with advanced liver disease	+	++	+++	++		+/-
Association with HCC	+ (subgeno A1)	+	++	++		++ (subgeno F2)
Early HBeAg seroconversion	++	+++	+	+++		+++
Sustained remission after HBeAg Seroconversion	+++	+++	++	++		++
HBsAg clearance	+++	++	+	++
Response to IFN Tx	+++	++	+	+/-	+	+++
Association with PreCore mutations	-	++	+	+++	++	+++ (F1 but not F2)
Association with BCP mutation	++		++		++

+/-: Possible association; - : No association; +: Slight association; ++: Moderate association; +++: Strong association. HBeAg: Hepatitis B e antigen; BCP; Basal core promotor; HCC: Hepatocellular carcinoma; IFN: Interferon.