PAI-1 4G-4G and MTHFR 677TT in non-hepatitis C virus/hepatitis B virus-related liver cirrhosis

doi:10.4254/wjh.v7.i29.2920

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Dec 18, 2015; 7(29): 2920-2926
Published online Dec 18, 2015. doi: 10.4254/wjh.v7.i29.2920

Table 2 Frequencies of thrombophilic genetic factors, PAI-1 4G-4G, MTHFR 677TT, V Leiden 506Q and prothrombin 20210A, in patients with hepatitis C/B virus liver cirrhosis, alcoholic and cryptogenic, aggregated as non-virus cirrhosis

	(A) VLC (%)	Alcoholic (%)	Crypto (%)	(B) NVLC (%)	(A) vs (B)χ²: P value; OR (95%CI)
Patients	729 (100)	102 (100)	248 (100)	350 (100)	-
PAI-1 4G-4G	95 (13.0)	33 (32.3)	89 (35.8)	122 (34.8)	68.2: 0.000; 3.6 (2.6-4.9)
MTHFR 677TT	99 (13.5)	14 (13.7)	63 (25.4)	77 (22.0)	11.7: 0.001; 1.8 (1.3-2.5)
V Leiden 506Q	41 (5.6)	9 (8.8)	22 (8.8)	30 (8.6)	3.3: 0.09; 1.5 (0.9-2.6)
Prothrombin 20210A	25 (3.4)	3 (2.9)	13 (5.2)	16 (4.5)	0.8: 0.39; 1.4 (0.7-2.7)
At least 1 THRGF	218 (29.9)	43 (42.1)	156 (62.9)	199 (56.9)	72.5: 0.000; 3.1 (2.4-4.1)
> 1 THRGF	40 (5.4)	14 (13.7)	30 (12.0)	44 (12.5)	16.5: 0.000; 2.5 (1.6-4.0)

VLC: Virus liver cirrhosis; NVLC: Non-virus cirrhosis; THRGF: Thrombophilic genetic factors.

Citation: Pasta L, Pasta F. PAI-1 4G-4G and MTHFR 677TT in non-hepatitis C virus/hepatitis B virus-related liver cirrhosis. World J Hepatol 2015; 7(29): 2920-2926
URL: https://www.wjgnet.com/1948-5182/full/v7/i29/2920.htm
DOI: https://dx.doi.org/10.4254/wjh.v7.i29.2920