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Copyright ©The Author(s) 2015.
World J Hepatol. Dec 8, 2015; 7(28): 2781-2791
Published online Dec 8, 2015. doi: 10.4254/wjh.v7.i28.2781
Table 1 Upregulated long noncoding RNAs in hepatocellular carcinoma
NameGene locusSize (bp)DysregulationPotential role in HCCRef.
HULC6p24.31638UpregulatedAssociate with HBV infection or histological grade. Associate with tumor growth[22,29,44-50]
H1911p15.52660UpregulatedSuppress progression, metastasis. Promote cell proliferation[22,29,50-57]
TUC33812q13.13590UpregulatedIncreased in liver cirrhosis. Modulate cell growth[58]
MALAT111q13.18708UpregulatedAssociate with tumor metastasis, recurrence[21,22,29,59,60]
HOTAIR12q13.1312649UpregulatedAssociate with invasion and metastasis. Increases chemosensitivity[21,22,29,61-65]
HOTTIP7p15.26839UpregulatedAssociate with tumor progression and disease outcome[28,66-68]
HEIH5q35.31665UpregulatedAssociated with HBV-HCC. Associate with prognosis[21,29,69]
MDIG3q11.230635UpregulatedAssociate with DNA repair and prognosis[70]
PVT18q24.21210626UpregulatedAssociate with HCC progression and predict recurrence[71,72]
Linc0097417q21.314890UpregulatedPredict tumor growth and metastasis[73]
UFC11q23.35113UpregulatedPromote HCC cell proliferation, inhibit cell apoptosis and induce cell cycle progression[10,12,74]
PCNA-AS120p12.3384UpregulatedPromote tumor growth[75]
UCA119p13.127375UpregulatedInvolved in chemotherapeutic resistance. Associatewith TNM stage, metastasis and postoperative survival[50,76]
CCAT18q24.2111887UpregulatedPromotes HCC progression[77-79]
ATB19q13.32895UpregulatedAssociat with poor prognosis[80,81]
URHC2q24.2192173UpregulatedPromote cell proliferation and inhibit apoptosis[82]