Importance of virological response in the early stage of telaprevir-based triple therapy for hepatitis C

Table 2 Precision rate for the prediction of sustained virological response and non-sustained virological response in the early stage of telaprevir-based triple therapy

	Patients who achieved SVR/patients with VR, n	PPV (%)	Patients who did not achieve SVR/patients without VR, n	NPV (%)	Kappa coefficient (95%CI)
Week 1	14/14	100	45/222	20.3	0.03 (0.01-0.05)
Week 2	52/52	100	44/185	23.8	0.12 (0.08-0.16)
Week 3	113/124	91.1	33/109	30.3	0.22 (0.12-0.33)
Week 4	168/182	92.3	26/64	40.6	0.38 (0.24-0.51)
Week 6	202/228	88.6	14/17	82.4	0.44 (0.27-0.61)
Week 8	200/232	86.2	5/8	62.5	0.18 (0.02-0.34)
Week 12	198/234	84.6	1/1	100	-

PPV: Positive predictive value, the probability that a patient with a given on-treatment virological response (VR) will achieve sustained virological response (SVR); NPV: Negative predictive value, the probability that a patient without a given on-treatment VR will not achieve SVR.