Hepatocellular carcinoma: A comprehensive review

Table 2 Criteria for listing for liver transplantation and hepatocellular carcinoma: Various expansion beyond the Milan Criteria

Criteria	Ref.	No. of patients	Selection criteria	Survival rate at 5 yr	Survival rate at 5 yr using MC
MC	Mazzaferro et al[4]	48	Solitary HCC < 5 cm or 3 nodules < 3 cm	75% (4 yr)	-
Up to seven criteria	Mazzaferro et al[86]	283	Sum of the number of tumors and diameter of the largest tumor ≤ 7 cm	71.2%	73.3%
Toronto Criteria	DuBay et al[109]	294	Dominant lesion not poorly differentiated on biopsy, no restriction on tumor size and number	68%	72%
UCSF Criteria	Yao et al[81]	70	Solitary tumor ≤ 6.5 cm or 3 nodules ≤ 4.5 cm in diameter with a total tumor diameter ≤ 8 cm	75.2%	72%
Clinica universitaria de Navarra Criteria	Herrero et al[110]	154	Solitary tumor ≤ 6 cm or ≤ 3 nodules ≤ 5 cm in diameter	68%	66%
Kyoto Criteria	Ito et al[41]	125	≤ 10 nodules all ≤ 5 cm in diameter protein induced by vitamin K absence or antagonist-II ≤ 400 mAU/mL	Overall survival 68.3%	No difference
Asan Criteria	Lee et al[111]	186	≤ 6 nodules with a maximum tumor diameter of ≤ 5 cm	76%	76.3%
Bologna Criteria	Del Gaudio et al[112]	177	Solitary HCC ≤ 6 cm or 2 nodules ≤ 5 cm or	71% (3 yr)	71% (3 yr)
			< 6 nodules ≤ 4 cm and sum diameter ≤ 12 cm
Metroticket Calculator	Mazzaferro et al[86]	> 1000	International Liver Transplant Society meeting in 2005 as a Web-based survey. Predict 5 yr survival based on tumor size	50%-70%	75%-80%
Toso Criteria	Toso et al[113]	288	Total tumor volume ≤ 115 cm3	80%	82%
Silva Criteria	Boin et al[114]	257	≤ 3 nodules with a maximum tumor diameter of ≤ 5 cm and total tumor diameter < 10 cm	69%	62%
Hangzhou Criteria	Fan et al[87]	195	Total tumor diameter < 8 cm with grate I or II tumor on biopsy and AFP < 400 ng/mL	72%	78%

HCC: Hepatocellular carcinoma; MC: Milan Criteria; AFP: Alpha feto protein.