Role of pentoxifylline in non-alcoholic fatty liver disease in high-fat diet-induced obesity in mice

doi:10.4254/wjh.v7.i24.2551

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Oct 28, 2015 (publication date) through May 1, 2024

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Oct 28, 2015; 7(24): 2551-2558
Published online Oct 28, 2015. doi: 10.4254/wjh.v7.i24.2551

Table 4 Hepatic cytokines in lean (control) and obese (high-fat diet) mice treated with pentoxifylline

	Control		HFD
	NT	PTX	NT	PTX
TNF-α (pg/mL)	29.6 ± 6.6	75.4 ± 12.6^c	156.3 ± 17.2^a	62.6 ± 7.6^c
IL-10 (pg/mL)	27.2 ± 3.6	37.3 ± 8.3	27.5 ± 5.2	29.4 ± 8.2
MCP-1 (pg/mL)	34.9 ± 4.9	56.2 ± 12.3	89.1 ± 10.8^a	112.3 ± 22.4

^aP < 0.05 vs control NT group;

^cP < 0.05 vs the matched NT group. HFD: High-fat diet; NT: Non-treated; PTX: Pentoxifylline; TNF-α: Tumor necrosis factor α; IL-10: Interleukin-10; MCP: Monocyte chemoattractant protein-1.

Citation: Acedo SC, Caria CREP, Gotardo &MF, Pereira JA, Pedrazzoli J, Ribeiro ML, Gambero A. Role of pentoxifylline in non-alcoholic fatty liver disease in high-fat diet-induced obesity in mice. World J Hepatol 2015; 7(24): 2551-2558
URL: https://www.wjgnet.com/1948-5182/full/v7/i24/2551.htm
DOI: https://dx.doi.org/10.4254/wjh.v7.i24.2551