Renal failure in cirrhosis: Emerging concepts

Table 4 International Club of Ascites-acute kidney injury criteria for diagnosis, grading, assessment of progression and response to treatment of acute kidney injury in patients with cirrhosis

Class	Baseline SCr within 3 mo, most recent prior to hospital admission	Urinary output
I	↑ SCr ≥ 0.3 mg/dL or ↑ SCr 1.5-1.9 times over baseline1	Not required
II	↑ SCr 2.0-2.9 times over baseline1	Not required
III	↑ SCr ≥ 3 times over baseline or if baseline SCr ≥ 4 mg/dL: ↑ SCr ≥ 0.3 mg/dL1 or initiation of renal replacement therapy	Not required
Progression of AKI	Progression of AKI to a higher stage and/or need for renal replacement therapy
Regression of AKI	Regression of AKI to a lower stage
No response	No regression of AKI
Partial response	Regression of AKI stage with a reduction of SCr to ≥ 0.3 mg/dL above the baseline value
Full response	Return of SCr to a value within 0.3 mg/dL of the baseline value

¹Which is known, or presumed, to have occurred within the prior 7 d. Adapted from Angeli et al[14]. SCr: Serum creatinine; AKI: Acute kidney injury.