Management before hepatectomy for hepatocellular carcinoma with cirrhosis

Table 4 Reports on liver resection and splenectomy for hepatocellular carcinoma complicated by hepatic cirrhosis accompanied by hypersplenism

Year	Ref.	Simultaneous splenectomy, 2-stage (No. of patients)	Platelet count (×104/μL)	Child-Pugh (A/B/C)	Mortality	Morbidity	Survival rate	Effect
1989	Takayama et al[38]	Simultaneous (12), 2-stage (8)	4.6	N	N	N	N	Expansion of indication of liver resection
1999	Lin et al[94]	Simultaneous (11)	5.2 ± 1.5	5/6/0	9.1%	27.3%	5 yr recurrence-free 66.7%	Improvement of serum bilirubin level
2000	Sugawara et al[49]	Simultaneous (35), 2-stage (13)	4.7 ± 0.3	N	0	47.9	3/5 yr survival rate: 72.3%/38.9%	Improvement of safety
2000	Shimada et al[95]	2-stage (6)	5.2 ± 1.5	1/4/1	0	17	N	Improvement of platelet count, albumin level, and Child classification
2003	Oh et al[96]	Simultaneous (12), no sp (6)	5.5 ± 1.5	10/8/0	11.1	66.7	N	Expansion of indication of liver resection
2004	Wu et al[97]	Simultaneous (41), no sp (485)	3.8 ± 2.1	419/85/23	1.5	20.5	N	Improvement of recurrence-free survival rate
2005	Chen et al[98]	Simultaneous (94), no sp (110)	6.2	125/79/0	N	15.2	5 yr survival 56%, recurrence-free survival 35%	Improvement of recurrence-free survival rate
2008	Sugimachi et al[99]	Simultaneous (4), no sp (11)	4.2 ± 0.8	9/6/0	6.7	47	N	3-yr survival rate equivalent to that after conventional liver resection
2015	Zhang et al[100]	Simultaneous (84), no sp (84)	6.1 ± 4.2	84/0/0	0	39.3	1/3/5 yr survival: 90%/78%/66%	Improvement of recurrence-free survival rate

N: Details unknown.