Management before hepatectomy for hepatocellular carcinoma with cirrhosis

Table 1 Prediction formula and discriminating factors for hepatic cirrhosis

Year	Ref.	Formula
2000	Ikeda et al[14]	Z = (0.124) × [γ globulin (%)] + (0.001) × hyaluronic acid (ng/mL) + (0.075) × platelet count (104/μL) + (-0.413) × gender (male = 1, female = 2) + (-2.005)
		The condition is hepatic cirrhosis when Z is positive, and chronic hepatitis when Z is negative
2007	Koda et al[15]	Fibroindex = (1.738) + (-0.064) × platelet count (104/μL) + (0.005) × AST (IU/L) + (0.463) × [γ globulin (g/dL)]
		The fibroindex value corresponds to fibrosis stage
2003	Wai et al[16]	APRI = 100 × [AST level/(upper limit of normal AST)/platelet count (× 109/L)]
2006	Sterling et al[17]	FIB-4 = [age × AST (U/L)]/[platelet count (× 109/L) × ALT (U/L)1/2]

APRI: AST to platelet ratio index; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; FIB-4: Fibroindex-4.