Basic Study
Copyright ©The Author(s) 2015.
World J Hepatol. Jul 18, 2015; 7(14): 1875-1883
Published online Jul 18, 2015. doi: 10.4254/wjh.v7.i14.1875
Table 2 Demographic, clinical, laboratory and histological baseline characteristics of 187 patients according to cartilage oligomeric matrix protein antigen positivity
COMP-positive (n = 52)COMP-negative (n = 135)P value
Sex (male/female), n (%)26/26 (50%/50%)69/66 (51.1%/48.9%)1.000
Age (yr), mean ± SD61.7 ± 11.950.9 ± 15.3< 0.001
Duration of follow-up (mo)45 (91)107 (95)< 0.01
INR1.15 (0.22)1 (0.17)0.002
Platelets (× 103/μL)166 (125)199 (104)0.008
AST (U/L)59 (57)31 (33)< 0.001
ALT (U/L)46 (50)38 (39)< 0.02
γ-GT (U/L)50 (65)27 (48)0.003
ALP (U/L)115 (102)83 (63)0.001
Bilirubin (mg/dL)1.1 (1.5)0.7 (0.6)< 0.05
Albumin (g/dL)3.9 (1)4.4 (1)< 0.001
IgG (mg/dL), mean ± SD1724 ± 6141533 ± 4610.151
IgM (mg/dL)134 (180)135 (120)0.265
IgA (mg/dL), mean ± SD359 ± 196295 ± 1900.196
AFP (ng/mL)6.9 (10.5)3.8 (5.5)< 0.02
Cirrhosis (yes/no), n (%)43/9 (82.7%/17.3%)55/80 (40.7%/59.3%)< 0.001
Decompensation of cirrhosis1 (yes/no), n (%)11/32 (25.6%/74.4%)16/39 (29.1%/70.9%)0.874
HCC (yes/no), n (%)7/45 (13.5%/86.5%)5/130 (3.7%/96.3%)< 0.05
Histological grade (none/minimal/mild vs moderate/severe), n (%)5/17 (22.7%/77.3%)56/32 (63.6%/36.4%)0.001
Histological stage (none/minimal/mild vs moderate/severe/cirrhosis), n (%)5/17 (22.7%/77.3%)57/31 (64.8%/35.2%)0.001
1Decompensation of cirrhosis denotes the development of at least one of the following: variceal bleeding, hepatic encephalopathy or ascites. Data are present as median (interquartile range) unless other indicated; n: Number of patients in each respective group; COMP: Cartilage oligomeric matrix protein; SD: Standard deviation; INR: International normalized ratio; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; γ-GT: γ-glutamyl transpeptidase; ALP: Alkaline phosphatase; IgG: Immunoglobulin G; IgM: Immunoglobulin M; IgA: Immunoglobulin A; AFP: Alpha fetoprotein; HCC: Hepatocellular carcinoma.