Guide for diagnosis and treatment of hepatocellular carcinoma

Table 3 MicroRNAs with potential prognostic impact in patients with hepatocellular carcinoma

MiRNAs	Molecular alteration	Clinical significance	Ref.
20 miRNAs	Signature	Venous metastasis, overall survival	[154]
19 mi NAs	Signature	Poor survival	[155]
MiR-19a, miR-886-5p, miR-126, miR-233, miR-24, and miR-147	Signature	Predictor of overall survival and recurrence-free survival after LT	[156]
MiR-26a	Down-regulation	Poor survival	[157]
MiR-122	Down-regulation	Gain of metastasis properties	[158,159]
MiR-122	Down-regulation	Early recurrence	[160]
Let-7 members	Down-regulation	Early recurrence	[161]
MiR-199a-3p	Down-regulation	Reduced time to recurrence	[162]
MiR-199b-5p	Down-regulation	Poor overall survival and progression-free survival rates	[163]
MiR-101	Down-regulation	Advanced tumour progression, poor prognosis	[164]
MiR-125a	Up-regulation	Better survival	[165]
MiR-92, miR-20, miR-18	Up-regulation	Poor differentiation	[166]
MiR-372	Up-regulation	Advanced TNM stage	[167]
MiR-221	Up-regulation	Multi-nodularity, reduced time to recurrence	[168]
MiR-221	Up-regulation	Gain of metastatic properties	[169]
MiR-221	Up-regulation	High tumour capsular infiltration	[170]
MiR-17-5p	Up-regulation	Multiple tumour nodules, vein invasion, shortened overall survival	[171]
MiR-155	Up-regulation	High recurrence and poor prognosis following OLT	[172]
MiR-203	Up-regulation	Good prognosis	[173]
MiR-18	Up-regulation	Poor prognosis	[174]

Data adapted from Negrini et al[175]. MiRNAs: MicroRNAs; TNM: Tumour-node-metastasis; LT: Liver transplantation; OLT: Orthotopic liver transplantation.