MicroRNAs dysregulation in hepatocellular carcinoma: Insights in genomic medicine

Table 2 Downregulated microRNAs in hepatocellular carcinoma

MiRNA	Cellular process	Ref.
Let-7a	Apoptosis and proliferation	[107,108]
Let-7b	Apoptosis and proliferation	[109]
Let-7c	Apoptosis, proliferation and cell growth	[110-112]
Let-7d	Apoptosis and proliferation	[107]
Let-7f-1	Apoptosis and proliferation	[107]
Let-7g	Apoptosis and metastasis	[113-115]
MiR-1	Proliferation	[116]
MiR-34a	Metastasis	[96]
MiR-101	Apoptosis and DNA methylation	[110,117,118]
MiR-122	Apoptosis, metastasis and angiogenesis	[119-122]
MiR-124	Proliferation	[123]
MiR-125a	Proliferation, metastasis and metabolism	[124-126]
MiR-125b	Proliferation, metastasis, angiogenesis, apoptosis and histone modification	[110,125-127]
MiR-139	Metastasis	[128,129]
MiR-138	Cell cycle	[130]
MiR-145	Cell growth and tumorigenesis	[131]
MiR-195	Tumorigenesis, cell cycle and apoptosis	[132,133]
MiR-199a-3p	Drug resistance and cell growth	[101,134]
MiR-199a-5p	Invasion and autophagy	[135]
MiR-200a	Proliferation and metastasis	[136]
MiR-203	Proliferation	[137]
MiR-214	Cell growth, metastasis and angiogenesis	[138,139]
MiR-219-5p	Proliferation	[140]
MiR-223	Proliferation	[141]
MiR-26a/b	Cell cycle	[142]
MiR-29a	Proliferation	[143]
MiR-34a	Metastasis	[96,144]
MiR-375	Autophagy	[145]
MiR-376a	Apoptosis and proliferation	[146]
MiR-449	Proliferation and apoptosis	[147]
MiR-450a	Proliferation	[148]
MiR-520b	Cell growth and proliferation	[149]
MiR-7	Tumorigenesis and metastasis	[150]

MiRNAs: MicroRNAs.