Chemokines and their receptors play important roles in the development of hepatocellular carcinoma

Table 1 Chemokines and chemokine receptors in hepatocellular carcinoma

Chemokines	Other names	Chemokine receptors	Subclass	Ref.
CXCL1	GROα	CXCR2	CXC	[20,21,83]
CXCL2	GROβ	CXCR2	CXC	[21,83]
CXCL5	ENA78	CXCR2	CXC	[21,22]
CXCL8	IL-8	CXCR1, CXCR2	CXC	[16,17,21]
CXCL9	MIG	CXCR3	CXC	[17,18,70]
CXCL10	IP-10	CXCR3	CXC	[17,29,51,70]
CXCL11	I-TAC	CXCR3, CXCR7	CXC	[14,50]
CXCL12	SDF-1	CXCR4, CXCR7	CXC	[12,13,15,86,89,92]
CXCL14	BRAK	Unknown	CXC	[23]
CXCL16	SR-PSOX	CXCR6	CXC	[49,106]
CCL2	MCP-1	CCR2	CC	[17,56,81,116]
CCL3	MIP-1α	CCR1, CCR5	CC	[27,28,81,122]
CCL4	MIP-1β	CCR5	CC	[29,48]
CCL5	RANTES	CCR1, CCR3, CCR5	CC	[27,29,100]
CCL15	HCC-2, leukotactin-1	CCR1, CCR3	CC	[33,100]
CCL17	TARC	CCR4	CC	[34,66]
CCL19	ELC, MIP-3β	CCR7	CC	[37,117-119]
CCL20	MIP-3α	CCR6	CC	[30-32]
CCL21	SLC	CCR7	CC	[37,117-119]
CCL22	MDC	CCR4	CC	[35,66]
CCL26	Eotaxin-3	CCR3, CX3CR1	CC	[110]
CCL27	CTACK, ILC	CCR10	CC	[36]
CX3CL1	Fractalkine	CX3CR1	CX3C	[39,40]

GRO: Growth regulated oncogene; ENA78: Epithelial neutrophil-activating protein 78; IL-8: Interleukin 8; MIG: Monokine induced by IFN-γ; IP-10: IFN-γ-induced protein 10; I-TAC: IFN-inducible T cell alpha chemoattractant; SDF-1: Stromal cell-derived factor 1; BRAK: Breast and kidney expressed chemokine; SR-PSOX: Scavenger receptor that binds phosphatidylserine and oxidized lipoprotein; MCP-1: Monocyte chemotactic protein 1; MIP-1α: Macrophage inflammatory protein-1α; HCC: Hepatocellular carcinoma; TARC: Thymus activation-regulated chemokine; ELC: Epstein-Barr virus-induced molecule 1 ligand CC chemokine; SLC: Secondary lymphoid tissue chemokine; MDC: Macrophage-derived chemokine; CTACK: Cutaneous T-cell-attracting chemokine; ILC: Interleukin-11 receptor α-locus chemokine; IFN: Interferon.