Diagnostic and therapeutic application of noncoding RNAs for hepatocellular carcinoma

doi:10.4254/wjh.v7.i1.1

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Jan 27, 2015 (publication date) through Apr 26, 2024

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Jan 27, 2015; 7(1): 1-6
Published online Jan 27, 2015. doi: 10.4254/wjh.v7.i1.1

Table 2 Representative noncoding RNAs under clinical and preclinical trials for hepatocellular carcinoma therapeutics

Target	Name	Content	Vendor	Current status
MiR34	MRX34	Liposome-formulated miR-34 mimic	Mirna Therapeutics	Phase I
VEGF/KSP	ALN-VSP	RNAi targeting VEGF/KSP	Alnylam Pharmaceuticals	Phase I
PLK1	TMK-PLK1	RNAi targeting PLK1	Tekmira Pharmaceuticals	Phase I/II
MiR21	Anti-miR21	Antisense against miR21	Regulus Therapeutics	Preclinical
MiR221	Anti-miR221	Antisense against miR221	Regulus Therapeutics	Preclinical
MiR7	MiR7 mimic	MiR7 mimic	MiReven	Preclinical

VEGF: Vascular endothelial growth factor; KSP: Kidney-specific cadherin; PLK1: Polo-like kinase 1.

Citation: Shibata C, Otsuka M, Kishikawa T, Ohno M, Yoshikawa T, Takata A, Koike K. Diagnostic and therapeutic application of noncoding RNAs for hepatocellular carcinoma. World J Hepatol 2015; 7(1): 1-6
URL: https://www.wjgnet.com/1948-5182/full/v7/i1/1.htm
DOI: https://dx.doi.org/10.4254/wjh.v7.i1.1