Pictures of focal nodular hyperplasia and hepatocellular adenomas

Figure 13 β-catenin activated, inflammatory hepatocellular adenoma. A-F: Man born in 1971. BMI 21.6 kg/m². By chance, discovery of one nodule 6 cm. Imaging: focal nodular hyperplasia. Right hepatectomy 2006. A: Fresh specimen: pigmented, irregular tumor. Non tumoral liver is normal. B: HE: Hepatocellular adenoma with sinusoidal dilatation and inflammatory infiltrate (on the left); large vessels at the junction with non tumoral liver. C: Diffuse expression of C-reactive protein by tumoral hepatocytes, with sharp demarcation from the non tumoral liver. D: Strong and diffuse glutamine synthase (GS) expression contrasting with normal staining of GS in adjacent non tumoral liver (in a few pericentrolobular hepatocytes). E: Large areas are positive for CD34, but not diffuse diffusely; F: Aberrant nuclear and cytoplasmic expression of β-catenin in quite numerous hepatocytes.