Assessing liver injury associated with antimycotics: Concise literature review and clues from data mining of the FAERS database

Table 1 MedDRA preferred terms used to retrieve liver events in FAERS

PT	Liver injury	Acute hepatic failure
Acute hepatic failure		X
Alanine aminotransferase abnormal	X
Alanine aminotransferase increased	X
Ammonia increased	X
Aspartate aminotransferase abnormal	X
Aspartate aminotransferase increased	X
Bilirubin conjugated increased	X
Bilirubin urine	X
Blood bilirubin abnormal	X
Blood bilirubin increased	X
Blood bilirubin unconjugated increased	X
Cholestasis	X
Coma hepatic		X
Cytolytic hepatitis	X
Hepatic encephalopathy		X
Hepatic enzyme abnormal	X
Hepatic enzyme increased	X
Hepatic failure		X
Hepatic function abnormal	X
Hepatic necrosis	X
Hepatitis	X
Hepatitis acute	X
Hepatitis cholestatic	X
Hepatitis fulminant		X
Hepatitis toxic	X
Hepatocellular damage	X
Hepatotoxicity	X
Hyperammonaemia	X
Hyperbilirubinaemia	X
Jaundice	X
Jaundice cholestatic	X
Jaundice hepatocellular	X
Liver function test abnormal	X
Liver injury	X
Liver transplant		X
Mixed hepatocellular-cholestatic injury	X
Subacute hepatic failure	X
Transaminases abnormal	X
Transaminases increased	X
Urine bilirubin increased	X

PT: Preferred term of the MedDRA terminology. “X” indicates that the PT was used to define the liver event; MedDRA: Medical Dictionary for Regulatory Activities.