Pooled genetic analysis in ultrasound measured non-alcoholic fatty liver disease in Indian subjects: A pilot study

Table 3 Comparison of variant carriers between patients and controls

SNP-	Allele frequency controls (n = 150)		Allele frequency patients (n = 156)		χ2	P value	Corrected P value1	OR	95%CI
gene name	Major	Minor	Major	Minor					lower-upper
rs1227756	0.49	0.51	0.44	0.56	0.02	0.88	0.93	1.04	0.54-2.03
COL13A1
rs12137855	0.77	0.23	0.73	0.27	0.41	0.51	0.62	1.20	0.68-2.12
LYPLAL1
rs1390096	0.68	0.32	0.66	0.34	0.007	0.93	0.93	0.97	0.55-1.70
HS3ST1-HSP
rs1421201	0.88	0.12	0.85	0.15	1.60	0.20	0.36	1.55	0.78-3.10
intronic
rs2073080	0.81	0.19	0.69	0.31	8.42	0.003	0.02	2.36	1.31-4.22
PARVB
rs2143571	0.80	0.20	0.69	0.31	6.25	0.01	0.05	2.07	1.16-3.69
SAMM50
rs2228603	0.97	0.03	0.92	0.08	4.09	0.04	0.12	3.29	1.10-9.84
NCAN
rs2499604	0.53	0.47	0.60	0.40	3.76	0.05	0.13	1.92	0.98-3.75
intronic
rs2645424	0.5	0.50	0.56	0.44	1.21	0.27	0.40	0.69	0.36-1.32
FDFT1
rs2710833	0.60	0.40	0.66	0.34	3.09	0.07	0.17	0.56	0.30-1.07
intronic
rs2854117	0.58	0.42	0.55	0.45	4.24	0.03	0.12	1.83	1.02-3.28
APOC3
rs343062	0.55	0.45	0.52	0.48	1.96	0.16	0.32	1.53	0.84-2.80
intronic
rs4240624	0.94	0.06	0.91	0.09	1.21	0.27	0.40	1.56	0.69-3.52
PPP1R3B
rs6487679	0.89	0.11	0.75	0.25	9.65	0.001	0.01	2.81	1.44-5.48
PZP
rs6591182	0.63	0.37	0.59	0.41	0.99	0.31	0.44	1.39	0.72-2.67
intronic
rs738409	0.92	0.08	0.60	0.40	46.37	0.0001	0.001	12.66	5.45-29.38
PNPLA3
rs780094	0.76	0.24	0.74	0.26	0.48	0.48	0.62	1.22	0.69-2.15
GCKR
rs887304	0.82	0.18	0.83	0.17	0.19	0.65	0.73	0.87	0.47-1.59
EFCAB4B
rs11206226	1.00	0.00	1.00	0.00	-	-		-	-
YIPF1

¹Benjamini and Hochberg false discovery rate correction was applied to the “P value”. PNPLA3: Patatin-like phospholipase domain containing 3; NCAN: Neurocan; GCKR: Glucokinase regulatory protein; LYPLAL1: Lysophospholipase-like protein 1; PPP1R3B: Protein phosphatase 1, regulatory subunit 3B; PZP: Pregnancy zone protein.