Management of cytomegalovirus infection and disease in liver transplant recipients

Table 4 Currently available antiviral drugs for cytomegalovirus prophylaxis and treatment in liver transplant recipients

Drug	Route	Usual adult prophylaxis dose	Usual adult treatment dose	Comments on use and major toxicity
Ganciclovir	Intravenous	5 mg/kg once daily	5 mg/kg twice daily	Intravenous access; leukopenia
Ganciclovir	Oral	1 g three times daily	Not applicable	Low oral bioavailability; high pill burden
Valganciclovir	Oral	900 mg once daily	900 mg twice daily	Ease of administration; leukopenia
Foscarnet	Intravenous	Not recommended	60 mg/kg every 8 h (or 90 mg/kg every 12 h)	Second-line drug Intravenous access; nephrotoxicity
Cidofovir	Intravenous	Not recommended	5 mg/kg once weekly × 2 then every 2 wk thereafter	Third-line drug Intravenous access; nephrotoxicity