Central hepatectomy for centrally located malignant liver tumors: A systematic review

Table 2 Summary of case-control studies comparing central hepatectomies and lobar/extended hepatectomies n (%)

Ref.	Year	Resection type	n	Operative time (min)	Blood loss (mL)	Mortality	Morbidity	Complications (n)
Wu et al[17]	1999	Central hepatectomy	15	474	2450	0 (0)	3 (20)	Bile leak (1), pleural effusion (1), ascites (1)
		Extended hepatectomy	25	348	1863	1 (4)	6 (24)	Bile Leak (2), pleural effusion (1), ascites (1), prolonged jaundice (2), intra-abdominal abscess (2), wound infection (1)
			P value	0.09	0.23	0.43	0.99	-
Scudamore et al[19]	2000	Central hepatectomy	18	238	914	0 (0)	1intra (5.5)	Intraoperative bleeding (1), pneumonia (2), intra-abdominal fluid collection (2), fever longer than 48 hours (2), transient fever (2), bile leak (1), late intra-abdominal fluid collection (1)
		Lobar hepatectomy	71	222	1025	1 (1.4)	9early (50)	NA
							1late (5.6)
							6intra (8.5)
							29early (40.8)
							3late (4.2)
		Extended hepatectomy	43	304	1628	0 (0)	2intra (4.7)	NA
							21early (48.9)
							9late (20.9)
			P value	< 0.001	0.009 for extended vs central	-	0.05 for late complications	-
Hu et al[23]	2003	Central hepatectomy	52	265	NA	0 (0)	9 (17)	Bile leak (3), pleural effusion (3), 1 postoperative massive ascites (1), subphrenic abscess (1)
		Conventional or extended hepatectomy	63	264	NA	2 (3.1)	12 (19)	Bile leak (2), wound infection (4), pneumonia (2), liver failure (2), subphrenic abscess (1), pleural effusion (1)
			P value	0.953		0.408	0.491	-
Cheng et al[8]	2012	Central hepatectomy	63	230	500	5 (7.9)	8 (12.7)	Liver failure (2), bile leak (1)1
		Hemi-/extended hepatectomies	41	316	750	3 (7.3)	6 (14.6)	Liver failure (2), bile leak (1)
			P value	< 0.001	0.004	1.000	0.777	-
Total		Central hepatectomy	148	Mean 268	Mean 882	3.4% (0%-7.9%)	20.90% (range: 20%-66.7%)
		Hemi-/extended hepatectomies	243	Mean 299	Mean 1352	2.9% (0%-7.3%)	38.70% (range: 14.6%-74.4% )

¹Other complications described included gastrointestinal bleeding, intra-abdominal hematoma, abscess, intra-abdominal bleeding, pneumonia, wound infection, but did not specify the treatment group in which it occurred. Weighted means were calculated for operative time and blood loss. NA: Not available.