NS3 protease inhibitors for treatment of chronic hepatitis C: Efficacy and safety

Table 6 Adverse events under triple therapy

AgentRCT	Boceprevir
	SPRINT-2		RESPOND-2
	PR48	PR4/ PRB24/44	PR48	PR4/ PRB32/44
Serious AE	9%	11%-12%	5%	10%-14%
Discontinued AVT due to AE	16%	12%-16%	2%	8%-12%
Anorectal symptoms	-	-	-	-
Taste disturbances	18%	37%-43%	11%	43%-45%
Anemia	29%	49%	20%	43%-46%
Severe neutropenia	14%	24%-25%	9%	19%-20%
Rash	23%	25%-24%	5%	17%-14%
Fatigue	60%	53%-57%	50%	53.7%-57.1%
Pruritus	27%	24%-26%	17.50%	18.5%-19.3%
Nausea	42%	48%-43%	37.50%	43.8%-39.1%
Diarrhea	22%	22%-27%	15%	22.8%-23%

AE: Adverse event; AVT: Antiviral treatment.